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Journal of Obesity
Volume 2013 (2013), Article ID 361781, 10 pages
http://dx.doi.org/10.1155/2013/361781
Clinical Study

Effects of Roux-en-Y Gastric Bypass on Fasting and Postprandial Levels of the Inflammatory Markers YKL-40 and MCP-1 in Patients with Type 2 Diabetes and Glucose Tolerant Subjects

1Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, 2100 Copenhagen, Denmark
2Department of Medicine, Center of Endocrinology and Metabolism, Copenhagen University Hospital Herlev, Herlev Ringvej 75, 2730 Herlev, Denmark
3Department of Internal Medicine, Amager Hospital, Italiensvej 1, 2300 Copenhagen, Denmark
4Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 1, 2100 Copenhagen, Denmark
5Department of Endocrinology, Hvidovre Hospital, Kettegård Alle 30, 2650 Hvidovre, Denmark

Received 11 July 2013; Revised 9 September 2013; Accepted 15 September 2013

Academic Editor: Aimin Xu

Copyright © 2013 Stine Brinkløv Thomsen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The inflammatory markers YKL-40 and monocyte chemoattractant protein-1 (MCP-1) are elevated in morbidly obese patients and decline after weight loss. The objective of our study was to investigate the possible changes of YKL-40 and MCP-1, in both the fasting and the postprandial states, following Roux-en-Y gastric bypass (RYGB) in subjects with type 2 diabetes (T2D) and normal glucose tolerance (NGT). Methods. Ten obese patients with T2D and 10 subjects with NGT were examined in the fasting state and after a standard meal prior to and after (1 week, 3 months, and 1 year) RYGB. Results. Fasting state MCP-1 levels decreased after RYGB in both groups ( values < 0.0001) whereas fasting YKL-40 levels were unchanged ( values ≥ 0.120). Postprandial MCP-1 levels showed a tendency towards a decrease on most study days; however, the changes were only significant at 1 week ( ) and 1 yr ( ) in the T2D group and at 3 mo after RYGB in the NGT group ( ). YKL-40 levels showed a slight, postprandial suppression on all study days in the T2D group (all values ≤ 0.021). Conclusions. Fasting MCP-1 levels, but not YKL-40 levels, decrease after RYGB in subjects with T2D and NGT. Postprandial changes of inflammatory markers are discrete and inconsistent.