Table 2: I-AUC values for postprandial concentrations of YKL-40, MCP-1, FFA, and triglycerides in subjects with type 2 diabetes and normal glucose tolerance before (pre) and 1 wk, 3 mo, and 1 yr after Roux-en-Y gastric bypass.

Pre1 wk value3 mo value1 yr value

(% of total)T2D10 (50)9 (47)10 (53)10 (50)
NGT10 (50)10 (53)9 (47)10 (50)

I-AUC YKL-40, μg/L/t*T2D−31.38
(−56.0; −13.72)
5.25
(−10.56; 12.25)
0.008−27.56
(−64.90; −18.00)
0.866−0.75
(−12.56;13.94)
0.007
NGT−18.44
(−31.69; −6.41)
−0.19
(−16.53; 6.60)
0.386−15.38
(−20.31; 5.56)
0.260−2.75
(−13.35; −17.78)
0.114
value0.1740.4140.0220.821

I-AUC MCP1, pg/mL/t*T2D−14.62
(−36.38; −0.19)
−8.81
(−16.58; −2.33)
0.139−8.80
(−27.02; 0.67)
0.721−7.65
(−17.14; −1.39)
0.114
NGT−7.78
(−21.28; −1.42)
−7.79
(−14.02; −1.63)
0.445−1.37
(−11.52; 21.01)
0.441−3.32
(−5.69; 2.65)
0.093
value0.7050.9350.1210.226

I-AUC FFA, mmol/L/t*T2D−1.14
(−1.84; −0.61)
−0.82
(−1.66; −0.64)
0.859−1.16
(−1.52; −0.94)
0.878−1.16
(−1.38; −0.64)
0.508
NGT−0.69
(−1.71; 0.49)
−0.68
(−1.19; −0.37)
0.333−1.36
(−1.75; −0.78)
0.441−0.77
(−1.24; 0.03)
0.203
value0.4500.1910.8060.151

I-AUC TG, mmol/L/t*T2D0.91
(0.26; 1.58)
0.11
(−0.18; 0.45)
0.0280.18
(−0.06; 0.49)
0.0130.46
(0.03; 0.70)
0.059
NGT0.92
(0.55; 1.52)
0.05
(−0.23; 0.22)
0.0070.31
(0.10; 0.59)
0.0110.30
(0.06; 0.60)
0.074
value0.7620.3060.4140.677

Median (IQR).
value: comparison between groups (T2D/NGT). Mann-Whitney U-test.
value: compared to baseline (pre). Wilcoxon matched-pairs signed-rank test.
I-AUC: incremental area under the curve; MCP-1: monocyte chemoattractant protein-1; FFA: free fatty acids; TG: triglycerides; T2D: type 2 diabetes; NGT: normal glucose tolerance.