Table 2: (a) MC4R variation and BMI in populations of African ancestry. (b) Degree of linkage disequilibrium between MC4R SNPs in Table 2(a) in the YRI population [12].
(a)

MC4R SNPPopulation (n, study, reference)Minor alleleMinor allele frequencyP value for association with BMI

rs17782313Meta-analysis, 6 AA cohorts (n = 4,992) [21]C0.290.082
South African adults (birth to age 20)
(n = 990) [17]
C0.250.045
African decent, adults (PAGE) [50]C0.290.04
Meta-analysis, 6 AA cohorts (n = 4,992) [21]0.02
(Effect opposite risk allele)
rs571312AA children CHOP (n = 3,723) [51]T0.3350.348
rs10871777AA children CHOP (n = 3,723) [51]G0.2860.161
rs476828AA children CHOP (n = 3,723) [51]G0.4120.825
rs1942880AA children CHOP (n = 3,723) [51]C0.4990.008
rs12457166AA children CHOP (n = 3,723) [51]A0.2300.013
rs633265Meta-analysis 6 AA cohorts (n = 4,992) [21]C0.220.455
AA children CHOP (n = 3,723) [51]C0.2480.075
rs477181Meta-analysis 6 AA cohorts (n = 4992) [21]G0.470.018
AA children CHOP (n = 3,723) [51]G0.4920.252
rs4450508Meta-analysis, 6 AA cohorts (n = 4,992) [21]A0.300.046
rs6567160AA (n = 743), Nigerian (n = 1,188) [52]C (reference allele)0.0035
AA adults (GCI) (n = 494) [52]C (reference allele)0.227
AA adults (Maywood) (n = 756) [52]C (reference allele)0.024
African-derived adults (Jamaica G × E)
(n = 959) [52]
C (reference allele)0.497
African-derived adults (Jamaica SPT)
(n = 1,478) [52]
C (reference allele)0.021

(b)

(YRI)rs17782313rs571312rs10871777rs476828rs1942880rs12457166rs633265rs477181rs4450508rs6561760

rs177823131
rs5713120.2581
rs108717770.9240.2041
rs4768280.5030.4720.5441
rs19428800.2060.1210.2270.2411
rs124571660.0000.0010.0010.0040.0741
rs6332650.0640.0830.0690.1270.1500.0411
rs4771810.1400.1180.1660.3290.0130.2550.1611
rs44505080.1310.0020.1840.3400.0080.1030.0670.4131
rs65617600.0860.0120.0680.0000.1720.0680.0350.0070.0421