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Journal of Obesity
Volume 2013 (2013), Article ID 409679, 9 pages
Clinical Study

Metabolic Risk Susceptibility in Men Is Partially Related to Adiponectin/Leptin Ratio

Center for Human Nutrition and Departments of Clinical Nutrition, Internal Medicine and The Metabolic Unit of the Veterans Administration North Health Science Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9052, USA

Received 5 December 2012; Revised 1 February 2013; Accepted 1 February 2013

Academic Editor: Anne E. Sumner

Copyright © 2013 Gloria Lena Vega and Scott M. Grundy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. High adiponectin/leptin ratio may be protective from metabolic risks imparted by high triglyceride, low HDL, and insulin resistance. Methods. This cross-sectional study examines plasma adipokine levels in 428 adult men who were subgrouped according to low (<6.5 μg/mL)and high (≥6.5 μg/mL)adiponectin levels or a low or high ratio of adiponectin/leptin. Results. Men with high adiponectin/leptin ratio had lower plasma triglyceride and higher HDL cholesterol than those with low ratio. Similarly, those with high adiponectin/leptin ratio had lower TG/HDL cholesterol ratio and HOMA2-IR than those with low ratio. In contrast, levels of adiponectin or the ratio of adiponectin/leptin did not associate with systolic blood pressure. But the ratio of adiponectin/leptin decreased progressively with the increase in the number of risk factors for metabolic syndrome. Conclusion. Adipokine levels may reflect adipose tissue triglyceride storage capacity and insulin sensitivity. Leptin is an index of fat mass, and adiponectin is a biomarker of triglyceride metabolism and insulin sensitivity. Men with high adiponectin/leptin ratios have better triglyceride profile and insulin sensitivity than men with a low ratio regardless of waist girth.