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Journal of Obesity
Volume 2013 (2013), Article ID 489187, 5 pages
Role of Subcutaneous Adipose Tissue in the Pathogenesis of Insulin Resistance
Department of Medicine, Division of Endocrinology and Institute for Translational Science (ITS), University of Texas Medical Branch at Galveston, Galveston, TX 77555-1060, USA
Received 23 January 2013; Accepted 4 March 2013
Academic Editor: Manisha S. Chandalia
Copyright © 2013 Pavankumar Patel and Nicola Abate. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- A. Romero-Corral, V. K. Somers, J. Sierra-Johnson et al., “Normal weight obesity: a risk factor for cardiometabolic dysregulation and cardiovascular mortality,” European Heart Journal, vol. 31, no. 6, pp. 737–746, 2010.
- K. M. Flegal, M. D. Carroll, C. L. Ogden, and L. R. Curtin, “Prevalence and trends in obesity among US adults, 1999–2008,” Journal of the American Medical Association, vol. 303, no. 3, pp. 235–241, 2010.
- C. L. Ogden, M. D. Carroll, L. R. Curtin, M. M. Lamb, and K. M. Flegal, “Prevalence of high body mass index in US children and adolescents, 2007-2008,” Journal of the American Medical Association, vol. 303, no. 3, pp. 242–249, 2010.
- P. Poirier, T. D. Giles, G. A. Bray et al., “Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on obesity and heart disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism,” Circulation, vol. 113, no. 6, pp. 898–918, 2006.
- K. R. Fontaine, D. T. Redden, C. Wang, A. O. Westfall, and D. B. Allison, “Years of life lost due to obesity,” Journal of the American Medical Association, vol. 289, no. 2, pp. 187–193, 2003.
- V. Primeau, L. Coderre, A. D. Karelis et al., “Characterizing the profile of obese patients who are metabolically healthy,” International Journal of Obesity, vol. 35, no. 7, pp. 971–981, 2011.
- J. B. Meigs, P. W. F. Wilson, C. S. Fox et al., “Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 8, pp. 2906–2912, 2006.
- A. C. St-Pierre, B. Cantin, P. Mauriège et al., “Insulin resistance syndrome, body mass index and the risk of ischemic heart disease,” Canadian Medical Association Journal, vol. 172, no. 10, pp. 1301–1305, 2005.
- J. Arnlov, E. Ingelsson, J. Sundström, and L. Lind, “Impact of body mass index and the metabolic syndrome on the risk of cardiovascular disease and death in middle-aged men,” Circulation, vol. 121, pp. 230–236, 2010.
- J. L. Kuk and C. I. Ardern, “Are metabolically normal but obese individuals at lower risk for all-cause mortality?” Diabetes Care, vol. 32, no. 12, pp. 2297–2299, 2009.
- F. B. Ortega, D.-C. Lee, P. T. Katzmarzyk et al., “The intriguing metabolically healthy but obese phenotype: cardiovascular prognosis and role of fitness,” European Heart Journal, vol. 34, no. 5, pp. 389–397, 2013.
- M. L. Main, S. C. Rao, and J. H. O'Keefe, “Trends in obesity and extreme obesity among US adults,” Journal of the American Medical Association, vol. 303, no. 17, pp. 1695–1696, 2010.
- M. Chandalla, P. Lin, T. Seenivasan et al., “Insulin resistance and body fat distribution in South Asian men compared to Caucasian men,” PLoS ONE, vol. 2, no. 8, article e812, 2007.
- A. Garg, “Regional adiposity and insulin resistance,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 9, pp. 4206–4210, 2004.
- Y. Matsuzawa, I. Shimomura, T. Nakamura, Y. Keno, K. Kotani, and K. Tokunaga, “Pathophysiology and pathogenesis of visceral fat obesity,” Obesity Research, vol. 3, supplement 2, pp. 187S–194S, 1995.
- W. Y. Fujimoto, S. L. Abbate, S. E. Kahn, J. E. Hokanson, and J. D. Brunzell, “The visceral adiposity syndrome in Japanese-American men,” Obesity Research, vol. 2, no. 4, pp. 364–371, 1994.
- M. A. Banerji, N. Faridi, R. Atluri, R. L. Chaiken, and H. E. Lebovitz, “Body composition, visceral fat, leptin, and insulin resistance in Asian Indian men,” Journal of Clinical Endocrinology and Metabolism, vol. 84, no. 1, pp. 137–144, 1999.
- T. McLaughlin, C. Lamendola, A. Liu, and F. Abbasi, “Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 11, pp. E1756–E1760, 2011.
- A. Garg, “The role of body fat distribution in insulin resistance,” in Insulin Resistance; The Metabolic Syndrome X, G. M. Reaven and A. Laws, Eds., pp. 83–96, Humana Press, Totowa, NJ, USA, 1999.
- M. D. Jensen and C. M. Johnson, “Contribution of leg and splanchnic free fatty acid (FFA) kinetics to postabsorptive FFA flux in men and women,” Metabolism, vol. 45, no. 5, pp. 662–666, 1996.
- N. Abate, A. Garg, R. M. Peshock, J. Stray-Gundersen, and S. M. Grundy, “Relationships of generalized and regional adiposity to insulin sensitivity in men,” Journal of Clinical Investigation, vol. 96, no. 1, pp. 88–98, 1995.
- N. Abate, A. Garg, R. M. Peshock, J. Stray-Gundersen, B. Adams-Huet, and S. M. Grundy, “Relationship of generalized and regional adiposity to insulin sensitivity in men with NIDDM,” Diabetes, vol. 45, no. 12, pp. 1684–1693, 1996.
- B. H. Goodpaster, F. L. Thaete, J. A. Simoneau, and D. E. Kelley, “Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat,” Diabetes, vol. 46, no. 10, pp. 1579–1585, 1997.
- I. Ferreira, R. M. A. Henry, J. W. R. Twisk, W. Van Mechelen, H. C. G. Kemper, and C. D. A. Stehouwer, “The metabolic syndrome, cardiopulmonary fitness, and subcutaneous trunk fat as independent determinants of arterial stiffness: the Amsterdam Growth and Health Longitudinal Study,” Archives of Internal Medicine, vol. 165, no. 8, pp. 875–882, 2005.
- R. Ross, K. D. Shaw, J. Rissanen, Y. Martel, J. De Guise, and L. Avruch, “Sex differences in lean and adipose tissue distribution by magnetic resonance imaging: anthropometric relationships,” American Journal of Clinical Nutrition, vol. 59, no. 6, pp. 1277–1285, 1994.
- R. Ross, K. D. Shaw, Y. Martel, J. De Guise, and L. Avruch, “Adipose tissue distribution measured by magnetic resonance imaging in obese women,” American Journal of Clinical Nutrition, vol. 57, no. 4, pp. 470–475, 1993.
- R. Ross and J. Rissanen, “Mobilization of visceral and subcutaneous adipose tissue in response to energy restriction and exercise,” American Journal of Clinical Nutrition, vol. 60, no. 5, pp. 695–703, 1994.
- C. M. Apovian, S. Bigornia, M. Mott et al., “Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects,” Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 9, pp. 1654–1659, 2008.
- A. A. Bremer, S. Devaraj, A. Afify, and I. Jialal, “Adipose tissue dysregulation in patients with metabolic syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 11, pp. E1782–E1788, 2011.
- K.-A. Lê, S. Mahurkar, T. L. Alderete et al., “Subcutaneous adipose tissue macrophage infiltration is associated with hepatic and visceral fat deposition, hyperinsulinemia, and stimulation of NF-κB stress pathway,” Diabetes, vol. 60, no. 11, pp. 2802–2809, 2011.
- M. Lundgren, M. Svensson, S. Lindmark, F. Renström, T. Ruge, and J. W. Eriksson, “Fat cell enlargement is an independent marker of insulin resistance and‘hyperleptinaemia’,” Diabetologia, vol. 50, no. 3, pp. 625–633, 2007.
- F. H. J. Van Tienen, C. J. H. Van Der Kallen, P. J. Lindsey, R. J. Wanders, and H. J. M. Smeets, “Preadipocytes of type 2 diabetes subjects display an intrinsic gene expression profile of decreased differentiation capacity,” International Journal of Obesity, vol. 35, no. 9, pp. 1154–1164, 2011.
- J. H. Goedecke, J. Evans, D. Keswell et al., “Reduced gluteal expression of adipogenic and lipogenic genes in black South African women is associated with obesity-related insulin resistance,” Journal of Clinical Endocrinology and Metabolism, vol. 96, no. 12, pp. E2029–E2033, 2011.
- M. Chandalia, A. V. Cabo-Chan, S. Devaraj, I. Jialal, S. M. Grundy, and N. Abate, “Elevated plasma high-sensitivity C-reactive protein concentrations in Asian Indians living in the United States,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 8, pp. 3773–3776, 2003.
- O. Gealekman, N. Guseva, C. Hartigan et al., “Depot-specific differences and insufficient subcutaneous adipose tissue angiogenesis in human obesity,” Circulation, vol. 123, no. 2, pp. 186–194, 2011.
- M. B. Snijder, M. Visser, J. M. Dekker et al., “Low subcutaneous thigh fat is a risk factor for unfavourable glucose and lipid levels, independently of high abdominal fat. The Health ABC Study,” Diabetologia, vol. 48, no. 2, pp. 301–308, 2005.
- M. B. Snijder, P. Z. Zimmet, M. Visser, J. M. Dekker, J. C. Seidell, and J. E. Shaw, “Independent and opposite associations of waist and hip circumferences with diabetes, hypertension and dyslipidemia: the AusDiab Study,” International Journal of Obesity, vol. 28, no. 3, pp. 402–409, 2004.
- N. Abate and M. Chandalia, “Role of subcutaneous adipose tissue in metabolic complications of obesity,” Metabolic Syndrome and Related Disorders, vol. 10, no. 5, pp. 319–320, 2012.