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Journal of Obesity
Volume 2013 (2013), Article ID 492170, 9 pages
Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients
1Department of Food Science and Nutrition, Institute of Nutrition and Functional Foods (INAF), Laval University, Québec, QC, G1V 0A6, Canada
2Endocrinology and Nephrology, CHU de Québec Research Center, Québec, QC, G1V 4G2, Canada
3Québec Heart and Lung Institute, Québec, QC, G1V 4G5, Canada
4Department of Medicine, Laval University, Québec, QC, G1V 0A6, Canada
5Department of Surgery, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA
6Department of Surgery, Laval University, Québec, QC, G1V 0A6, Canada
Received 28 March 2013; Revised 17 May 2013; Accepted 22 May 2013
Academic Editor: Matthias Bluher
Copyright © 2013 Frédéric Guénard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- M. Z. Alfaradhi and S. E. Ozanne, “Developmental programming in response to maternal overnutrition,” Frontiers in Genetics, vol. 2, p. 27, 2011.
- S. B. Harrap, M. Stebbing, J. L. Hopper, H. N. Hoang, and G. G. Giles, “Familial patterns of covariation for cardiovascular risk factors in adults. The Victorian Family Heart Study,” American Journal of Epidemiology, vol. 152, no. 8, pp. 704–715, 2000.
- K. L. Whitaker, M. J. Jarvis, R. J. Beeken, D. Boniface, and J. Wardle, “Comparing maternal and paternal intergenerational transmission of obesity risk in a large population-based sample,” American Journal of Clinical Nutrition, vol. 91, no. 6, pp. 1560–1567, 2010.
- D. Dabelea, E. J. Mayer-Davis, A. P. Lamichhane et al., “Association of intrauterine exposure to maternal diabetes and obesity with type 2 diabetes in youth: the SEARCH case-control study,” Diabetes Care, vol. 31, no. 7, pp. 1422–1426, 2008.
- T. A. Hillier, K. L. Pedula, M. M. Schmidt, J. A. Mullen, M.-A. Charles, and D. J. Pettitt, “Childhood obesity and metabolic imprinting: the ongoing effects of maternal hyperglycemia,” Diabetes Care, vol. 30, no. 9, pp. 2287–2292, 2007.
- H. Hochner, Y. Friedlander, R. Calderon-Margalit et al., “Associations of maternal prepregnancy body mass index and gestational weight gain with adult offspring cardiometabolic risk factors: the jerusalem perinatal family follow-up study,” Circulation, vol. 125, no. 11, pp. 1381–1389, 2012.
- E. Villamor and S. Cnattingius, “Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study,” Lancet, vol. 368, no. 9542, pp. 1164–1170, 2006.
- J. E. Ramsay, W. R. Ferrell, L. Crawford, A. Michael Wallace, I. A. Greer, and N. Sattar, “Maternal obesity is associated with dysregulation of metabolic, vascular, and inflammatory pathways,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 9, pp. 4231–4237, 2002.
- T. Radaelli, J. Uvena-Celebrezze, J. Minium, L. Huston-Presley, P. Catalano, and S. Hauguel-de Mouzon, “Maternal interleukin-6: marker of fetal growth and adiposity,” Journal of the Society for Gynecologic Investigation, vol. 13, no. 1, pp. 53–57, 2006.
- M. J. Zhu, M. Du, P. W. Nathanielsz, and S. P. Ford, “Maternal obesity up-regulates inflammatory signaling pathways and enhances cytokine expression in the mid-gestation sheep placenta,” Placenta, vol. 31, no. 5, pp. 387–391, 2010.
- M. J. Zhu, Y. Ma, N. M. Long, M. Du, and S. P. Ford, “Maternal obesity markedly increases placental fatty acid transporter expression and fetal blood triglycerides at midgestation in the ewe,” American Journal of Physiology, vol. 299, no. 5, pp. R1224–R1231, 2010.
- J. Dahlgren, C. Nilsson, E. Jennische et al., “Prenatal cytokine exposure results in obesity and gender-specific programming,” American Journal of Physiology, vol. 281, no. 2, pp. E326–E334, 2001.
- G. C. Burdge, J. Slater-Jefferies, C. Torrens, E. S. Phillips, M. A. Hanson, and K. A. Lillycrop, “Dietary protein restriction of pregnant rats in the F0 generation induces altered methylation of hepatic gene promoters in the adult male offspring in the F1 and F2 generations,” British Journal of Nutrition, vol. 97, no. 3, pp. 435–439, 2007.
- K. A. Lillycrop, E. S. Phillips, C. Torrens, M. A. Hanson, A. A. Jackson, and G. C. Burdge, “Feeding pregnant rats a protein-restricted diet persistently alters the methylation of specific cytosines in the hepatic PPARα promoter of the offspring,” British Journal of Nutrition, vol. 100, no. 2, pp. 278–282, 2008.
- K. M. Godfrey, A. Sheppard, P. D. Gluckman et al., “Epigenetic gene promoter methylation at birth is associated with child's later adiposity,” Diabetes, vol. 60, no. 5, pp. 1528–1534, 2011.
- K. Szarc vel Szic, M. N. Ndlovu, G. Haegeman, and W. Vanden Berghe, “Nature or nurture: let food be your epigenetic medicine in chronic inflammatory disorders,” Biochemical Pharmacology, vol. 80, no. 12, pp. 1816–1832, 2010.
- A. E. Pontiroli, P. Pizzocri, M. C. Librenti et al., “Laparoscopic adjustable gastric banding for the treatment of morbid (grade 3) obesity and its metabolic complications: a three-year study,” Journal of Clinical Endocrinology and Metabolism, vol. 87, no. 8, pp. 3555–3561, 2002.
- N. Scopinaro, G. M. Marinari, G. B. Camerini, F. S. Papadia, and G. F. Adami, “Specific effects of biliopancreatic diversion on the major components of metabolic syndrome: a long-term follow-up study,” Diabetes Care, vol. 28, no. 10, pp. 2406–2411, 2005.
- P. Marceau, S. Biron, F.-S. Hould et al., “Duodenal switch: long-term results,” Obesity Surgery, vol. 17, no. 11, pp. 1421–1430, 2007.
- A. E. Pontiroli, F. Folli, M. Paganelli et al., “Laparoscopic gastric banding prevents type 2 diabetes and arterial hypertension and induces their remission in morbid obesity: a 4-year case-controlled study,” Diabetes Care, vol. 28, no. 11, pp. 2703–2709, 2005.
- L. Sjöström, A.-K. Lindroos, M. Peltonen et al., “Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery,” New England Journal of Medicine, vol. 351, no. 26, pp. 2683–2693, 2004.
- S. R. Rao, “Inflammatory markers and bariatric surgery: a meta-analysis,” Inflammation Research, vol. 61, no. 8, pp. 789–807, 2012.
- J. G. Kral, S. Biron, S. Simard et al., “Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years,” Pediatrics, vol. 118, no. 6, pp. e1644–e1649, 2006.
- J. Smith, K. Cianflone, S. Biron et al., “Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity,” Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 11, pp. 4275–4283, 2009.
- National Center for Health Statistics, “NHANES III clinical growth charts; children 2 to 20 years 5th to 95th percentile: boys' BMI for age and girls' BMI for age,” National Center for Health Statistics, Hyattsville, Md, USA, 2007.
- National Center for Health Statistics, “NHANES III Zscore data files: BMI for age and sex 2 to 20 years,” National Center for Health Statistics, Hyattsville, Md, USA, 2007.
- M.-C. Vohl, R. Sladek, J. Robitaille et al., “A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men,” Obesity Research, vol. 12, no. 8, pp. 1217–1222, 2004.
- M. Blazejczyk, M. Miron, and R. Nadon, “FlexArray: a statistical data analysis software for gene expression microarrays,” Genome Quebec, Montreal, Canada, 2007.
- V. G. Tusher, R. Tibshirani, and G. Chu, “Significance analysis of microarrays applied to the ionizing radiation response,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 9, pp. 5116–5121, 2001.
- P. A. Jones, “Functions of DNA methylation: islands, start sites, gene bodies and beyond,” Nature Reviews Genetics, vol. 13, no. 7, pp. 484–492, 2012.
- T. A. Rauch, X. Wu, X. Zhong, A. D. Riggs, and G. P. Pfeifer, “A human B cell methylome at 100-base pair resolution,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 3, pp. 671–678, 2009.
- K. Clément, N. Viguerie, C. Poitou et al., “Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects,” FASEB Journal, vol. 18, no. 14, pp. 1657–1669, 2004.
- A. R. Moschen, C. Molnar, S. Geiger et al., “Anti-inflammatory effects of excessive weight loss: potent suppression of adipose interleukin 6 and tumour necrosis factor a expression,” Gut, vol. 59, no. 9, pp. 1259–1264, 2010.
- C. L. Relton, A. Groom, B. St. Pourcain et al., “DNA methylation patterns in cord blood DNA and body size in childhood,” PLoS ONE, vol. 7, no. 3, Article ID e31821, 2012.
- K. Shankar, P. Kang, A. Harrell et al., “Maternal overweight programs insulin and adiponectin signaling in the offspring,” Endocrinology, vol. 151, no. 6, pp. 2577–2589, 2010.
- X. Yan, Y. Huang, H. Wang et al., “Maternal obesity induces sustained inflammation in both fetal and offspring large intestine of sheep,” Inflammatory Bowel Diseases, vol. 17, no. 7, pp. 1513–1522, 2011.
- K. Shankar, Y. Zhong, P. Kang et al., “Maternal obesity promotes a proinflammatory signature in rat uterus and blastocyst,” Endocrinology, vol. 152, no. 11, pp. 4158–4170, 2011.
- H.-M. Byun, K. D. Siegmund, F. Pan et al., “Epigenetic profiling of somatic tissues from human autopsy specimens identifies tissue- and individual-specific DNA methylation patterns,” Human Molecular Genetics, vol. 18, no. 24, pp. 4808–4817, 2009.
- R. P. Talens, D. I. Boomsma, E. W. Tobi et al., “Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology,” FASEB Journal, vol. 24, no. 9, pp. 3135–3144, 2010.
- H. R. Brattbakk, I. Arbo, and S. Aagaard, “Balanced caloric macronutrient composition downregulates immunological gene expression in human blood cells-adipose tissue diverges,” Omics, vol. 17, no. 1, pp. 41–52, 2011.
- C.-C. Liew, J. Ma, H.-C. Tang, R. Zheng, and A. A. Dempsey, “The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool,” Journal of Laboratory and Clinical Medicine, vol. 147, no. 3, pp. 126–132, 2006.
- I. Rudkowska, C. Raymond, A. Ponton et al., “Validation of the use of peripheral blood mononuclear cells as surrogate model for skeletal muscle tissue in nutrigenomic studies,” Omics, vol. 15, no. 1-2, pp. 1–7, 2011.
- J. T. Bell, A. A. Pai, J. K. Pickrell et al., “DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines,” Genome Biology, vol. 12, no. 1, article R10, 2011.
- F. Eckhardt, J. Lewin, R. Cortese et al., “DNA methylation profiling of human chromosomes 6, 20 and 22,” Nature Genetics, vol. 38, no. 12, pp. 1378–1385, 2006.
- B. C. Christensen, E. A. Houseman, C. J. Marsit et al., “Aging and environmental exposures alter tissue-specific DNA methylation dependent upon CPG island context,” PLoS Genetics, vol. 5, no. 8, Article ID e1000602, 2009.
- M. F. Fraga, R. Agrelo, and M. Esteller, “Cross-talk between aging and cancer: the epigenetic language,” Annals of the New York Academy of Sciences, vol. 1100, pp. 60–74, 2007.
- V. K. Rakyan, T. A. Down, S. Maslau et al., “Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains,” Genome Research, vol. 20, no. 4, pp. 434–439, 2010.
- L. Biertho, S. Lebel, S. Marceau et al., “Perioperative complications in a consecutive series of 1000 duodenal switches,” Surgery for Obesity and Related Diseases, vol. 9, no. 1, pp. 63–68, 2011.
- H. Buchwald, Y. Avidor, E. Braunwald et al., “Bariatric surgery: a systematic review and meta-analysis,” Journal of the American Medical Association, vol. 292, no. 14, pp. 1724–1737, 2004.
- S. M. Haffner, “The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease,” American Journal of Cardiology, vol. 97, no. 2, pp. 3A–11A, 2006.
- P. M. Ridker, N. Rifai, L. Rose, J. E. Buring, and N. R. Cook, “Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events,” New England Journal of Medicine, vol. 347, no. 20, pp. 1557–1565, 2002.