Journal of Obesity

Research Article

Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients

Correlations of gene methylation and expression with CRP levels for genes from the IL-8 signaling pathway.


Gene symbol	Methylation probe¹	Localization	Transcript accession number	Gene methylation versus expression ()		Gene methylation versus hsCRP level ()		Gene expression versus hsCRP level ()
Gene symbol	Methylation probe¹	Localization	Transcript accession number	Pearson	value	Pearson	value	Pearson	value

BCL2	cg08223235	Gene body	NM_000633		0.002		<0.0001		0.02
CCND2	cg27317813	Gene body	NM_001759		<0.0001		<0.0001		0.02
CXCR1	cg13048967	5′UTR	NM_000634		0.003		0.001		0.17
CXCR1	cg15768138	5′UTR	NM_000634		0.002		0.0004		0.17
GNA12	cg01139696	Gene body	NM_007353		0.02		0.32		0.33
GNA12	cg06544239	Gene body	NM_007353		0.004		0.32		0.33
GNA13	cg25554496	Gene body	NM_006572		0.01		0.0002		0.08
GNAI3	cg19244300	Gene body	NM_006496		0.04		0.0002		0.35
GNB2L1	cg01919999	Gene body	NM_006098		0.003		0.002		0.25
GNG2	cg27019717	5′UTR	NM_053064		0.004		<0.0001		0.12
GNG7	cg04603130	5′UTR	NM_052847		0.007		<0.0001		0.10
GNG7	cg24339704	5′UTR	NM_052847		0.007		<0.0001		0.10
GNG7	cg26988138	5′UTR	NM_052847		0.05		0.008		0.10
ITGAX	cg04742550	TSS200	NM_000887		0.03		0.01		0.38
LIMK2	cg07713946	3′UTR	NM_016733		0.03		0.001		0.06
MAP4K4	cg13522882	Gene body	NM_145687		0.04		0.0004		0.29
NCF2	cg09076123	5′UTR	NM_000433		0.04		0.0002		0.03
NCF2	cg09472600	Gene body	NM_000433		0.007		<0.0001		0.03
PIK3C2B	cg21195376	5′UTR	NM_002646		0.05		0.0004		0.28
PIK3R1	cg00067720	TSS1500	NM_181523		0.0008		<0.0001		0.01
PRKCA	cg14648237	Gene body	NM_002737		0.003		0.0001		0.06
PRKCA	cg22435313	Gene body	NM_002737		0.01		<0.0001		0.06
PRKCH	cg14001486	Gene body	NM_006255		<0.0001		<0.0001		0.04

Bold: significantly correlate in all 3 analyses.