About this Journal Submit a Manuscript Table of Contents
Journal of Obesity
Volume 2013 (2013), Article ID 610908, 7 pages
http://dx.doi.org/10.1155/2013/610908
Clinical Study

Safety and Efficacy of Glucomannan for Weight Loss in Overweight and Moderately Obese Adults

1Rush University College of Nursing, 600 S. Paulina Street, Suite 1080, Chicago, IL 60612, USA
2Rush University Medical Center, 1725 W. Harrison Street, Chicago, IL 60612, USA
3Section of Gastroenterology and Nutrition, Rush University Medical Center, 1725 W. Harrison Street, Chicago, IL 60612, USA
4North Park University School of Nursing, 3225 W. Foster Avenue, Chicago, IL 60625, USA
5Community, Systems, and Mental Health Nursing, Rush University College of Nursing, 600 S. Paulina Street, Suite 1080, Chicago, IL 60612, USA
6Faculty Practice, Rush University College of Nursing, 600 S. Paulina Street, Suite 1080, Chicago, IL 60612, USA

Received 4 September 2013; Revised 10 December 2013; Accepted 12 December 2013

Academic Editor: Jordi Salas-Salvadó

Copyright © 2013 Joyce K. Keithley et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Few safe and effective dietary supplements are available to promote weight loss. We evaluated the safety and efficacy of glucomannan, a water-soluble fiber supplement, for achieving weight loss in overweight and moderately obese individuals consuming self-selected diets. Methods. Participants were randomly assigned to take 1.33 grams of glucomannan or identically looking placebo capsules with 236.6 mL (8 ounces) of water one hour before breakfast, lunch, and dinner for 8 weeks. The primary efficacy outcome was change in body weight after 8 weeks. Other efficacy outcomes were changes in body composition, hunger/fullness, and lipid and glucose concentrations. Safety outcomes included gastrointestinal symptoms/tolerance and serum liver enzymes and creatinine levels. Results. A total of 53 participants (18–65 years of age; BMI 25–35 kg/m2) were enrolled and randomized. The two groups did not differ with respect to baseline characteristics and compliance with the study supplement. At 8 weeks, there was no significant difference between the glucomannan and placebo groups in amount of weight loss ( and , resp.) or other efficacy outcomes or in any of the safety outcomes. Conclusions. Glucomannan supplements administered over 8 weeks were well tolerated but did not promote weight loss or significantly alter body composition, hunger/fullness, or lipid and glucose parameters. This trial is registered with NCT00613600.