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Journal of Obesity
Volume 2013 (2013), Article ID 638154, 9 pages
http://dx.doi.org/10.1155/2013/638154
Research Article

Association of Obesity with Proteasomal Gene Polymorphisms in Children

1Faculty of Medicine, University of Latvia, Sarlotes Street 1a, Riga 1001, Latvia
2Institute of Biology, University of Latvia, Miera Street 3, Salaspils 2169, Latvia
3Institute of Experimental and Clinical Medicine, University of Latvia, No. 4 Ojara Vaciesa Street, Riga 1004, Latvia

Received 17 June 2013; Revised 29 October 2013; Accepted 22 November 2013

Academic Editor: Michel M. Murr

Copyright © 2013 Sarmite Kupca et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The aim of this study was to ascertain possible associations between childhood obesity, its anthropometric and clinical parameters, and three loci of proteasomal genes rs2277460 (PSMA6 c.-110C>A), rs1048990 (PSMA6 c.-8C>G), and rs2348071 (PSMA3 c. 543+138G>A) implicated in obesity-related diseases. Obese subjects included 94 otherwise healthy children in Latvia. Loci were genotyped and then analyzed using polymerase chain reactions, with results compared to those of 191 nonobese controls. PSMA3 SNP frequency differences between obese children and controls, while not reaching significance, suggested a trend. These differences, however, proved highly significant ( ) in the subset of children reporting a family history of obesity. Among obese children denying such history, PSMA6 c.-8C>G SNP differences, while being nonsignificant, likewise suggested a trend in comparison to the nonobese controls. No PSMA6 c.-110C>A SNP differences were detected in the obese group or its subsets. Finally, PSMA3 SNP differences were significantly associated ( ) with circulating low-density lipoprotein cholesterol (LDL) levels. Our results clearly implicate the PSMA3 gene locus as an obesity risk factor in those Latvian children with a family history of obesity. While being speculative, the clinical results are suggestive of altered circulatory LDL levels playing a possible role in the etiology of obesity in the young.