Association of Obesity with Proteasomal Gene Polymorphisms in Children

Table 3

Genotype frequencies in the obese case group (𝑛=94) and non-obese control group (𝑛=191).

Gene	SNP	Genotyping results
		Genotype	Subjects (𝑛)		Frequency (%)		Significance values
			Case	Control	Case	Control	𝑃	CI 95%
PSMA6	c.-110C>A	CC	83	166	88.3	86.9	0.74	0.43–1.85
		CA	11	25	11.7	13.1
		AA	0	0	0	0
	c.-8C>G	CC	78	158	83.0	82.7	0.43	0.59–1.97
		CG	14	32	14.9	16.8
		GG	2	1	2.1	0.5
PSMA3	c. 543+138G>A	GG	35	102	37.2	53.4	0.0008	0.85–1.8
		GA	54	66	57.5	34.6
		AA	5	23	5.3	12.0

SNP: single nucleotide polymorphism.
𝑃 value based on 𝜒² method and 10,000 permutations.
CI 95% indicates confidence interval.