The Impact of Rapid Weight Loss on Oxidative Stress Markers and the Expression of the Metabolic Syndrome in Obese Individuals

Table 3

Change in metabolic factors^b following rapid weight loss among 40 obese adults with the metabolic syndrome (values are expressed as means ± SE).

Metabolic factors	Baseline	Final	Change	Percent change	𝑃
Weight (kg)	116.84±3.8	99.92±3.2	−16.92±1.1	−14.32±0.7	<0.001
Waist (in)	45.14±1.0	40.53±1.1	−4.61±0.5	−10.23±1.0	<0.001
BMI (kg/m^2)	38.81±1.0	33.17±0.8	−5.64±0.3	−14.32±0.7	<0.001
SBP (mmHg)	136.63±2.9	128.04±2.0	−8.58±2.0	−5.50±1.4	<0.001
DBP (mmHg)	84.8±1.5	79.39±0.7	−5.41±1.4	−5.33±1.7	0.001
Glucose^a (mg/dL)	108.95±6.7	90.77±2.1	−18.18±7.2	−10.04±3.3	0.004
Insulin^a (mU/L)	27.40±4.1	11.30±2.2	−16.09±4.4	−36.77±14.8	<0.001
HOMA-IR^a	7.54±1.2	2.53±0.5	−5.01±1.2	−43.02±13.5	<0.001
Triglycerides^a (mg/dL)	254.7±24.4	123.76±8.2	−130.94±24.7	−38.09±6.1	<0.001
HDL (mg/dL)	44.1±1.7	38.57±1.5	−5.53±1.1	−11.11±2.6	<0.001
LDL (mg/dL)	121.18±5.2	109.20±4.6	−11.97±5.7	−4.51±5.6	0.041
Total cholesterol^a (mg/dL)	211.5±6.1	174.87±5.3	−36.28±5.3	−16.00±2.3	<0.001
ox-LDL (U/L)	64.26±2.2	54.69±1.8	−9.57±2.4	−11.97±3.4	<0.001
MPO^a (pM)	330.79±45.0	275.85±34.9	−54.93±50.5	−15.36±14.8	0.354
Lp-PLA2 activity (nmol/mL/min)	136.58±4.9	127.65±4.4	−8.93±3.8	−4.72±2.9	0.024

 ^a𝑃 value calculated using Wilcoxon matched-pairs signed-rank tests; all others using paired 𝑡-tests.
^bBased on data from visit 3. Missing data was filled in by applying the multiple imputation methods.