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Journal of Obesity
Volume 2013 (2013), Article ID 762012, 7 pages
http://dx.doi.org/10.1155/2013/762012
Research Article

Correlates of Adverse Outcomes in Abdominally Obese Individuals: Findings from the Five-Year Followup of the Population-Based Study of Health in Pomerania

1Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße NK, 17475 Greifswald, Germany
2German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, 13347 Berlin, Germany
3Medizinische Klinik—Innenstadt, Ludwig-Maximilians University, Ziemssenstraße 1, 80336 Munich, Germany
4Institute of Epidemiology and Social Medicine, University Medicine Greifswald, Walther-Rathenau-Straße 48, 17475 Greifswald, Germany
5Department of Cardiology, University Medicine Greifswald, Ferdinand-Sauerbruch-Straße NK, 17475 Greifswald, Germany
6Institute for Community Medicine, University Medicine Greifswald, Walther-Rathenau-Strße 48, 17475 Greifswald, Germany
7Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Friedrich-Ludwig-Jahn-Straße 15a, 17475 Greifswald, Germany

Received 21 March 2013; Accepted 26 August 2013

Academic Editor: Terry Huang

Copyright © 2013 Nele Friedrich et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Abdominal obesity is a major risk factor of cardiovascular disease (CVD), type 2 diabetes (T2DM), and premature death. However, it has not been resolved which factors predispose for the development of these adverse obesity-related outcomes in otherwise healthy individuals with abdominal obesity. Methods. We studied 1,506 abdominal obese individuals (waist-to-height ratio (WHtR) ≥ 0.5) free of CVD or T2DM from the population-based Study of Health in Pomerania and assessed the incidence of CVD or T2DM after a five-year followup. Logistic regression models were adjusted for major cardiovascular risk factors and liver, kidney diseases, and sociodemographic status. Results. During follow-up time, we observed 114 and 136 new T2DM and CVD cases, respectively. Regression models identified age, waist circumference, serum glucose, and liver disease as predictors of T2DM. Regarding CVD, only age, unemployment, and a divorced or widowed marital status were significantly associated with incident CVD. In this subgroup of obese individuals blood pressure, serum glucose, or lipids did not influence incidence of T2DM or CVD. Conclusion. We identified various factors associated with an increased risk of incident T2DM and CVD among abdominally obese individuals. These findings may improve the detection of high-risk individuals and help to advance prevention strategies in abdominal obesity.