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Journal of Obesity
Volume 2013 (2013), Article ID 764742, 11 pages
http://dx.doi.org/10.1155/2013/764742
Research Article

Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure: Relationship to Food Intake

1Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Charles R. Drew University of Medicine and Science and UCLA School of Medicine, 1731 E. 120th. Street, Los Angeles, CA 90059, USA
2Department of Pediatrics, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA 90027, USA
3College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA

Received 20 June 2013; Accepted 19 July 2013

Academic Editor: Yvon Chagnon

Copyright © 2013 Xiuhai Ren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. E. J. Nestler, “Molecular mechanisms of opiate and cocaine addiction,” Current Opinion in Neurobiology, vol. 7, no. 5, pp. 713–719, 1997. View at Publisher · View at Google Scholar · View at Scopus
  2. X. Guitart, M. A. Thompson, C. K. Mirante, M. E. Greenberg, and E. J. Nestler, “Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus,” Journal of Neurochemistry, vol. 58, no. 3, pp. 1168–1171, 1992. View at Scopus
  3. S. B. Lane-Ladd, J. Pineda, V. A. Boundy et al., “CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence,” Journal of Neuroscience, vol. 17, no. 20, pp. 7890–7901, 1997. View at Scopus
  4. J. A. Blendy, K. H. Kaestner, W. Schmid, P. Gass, and G. Schütz, “Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform,” EMBO Journal, vol. 15, no. 5, pp. 1098–1106, 1996. View at Scopus
  5. J. A. Blendy and R. Maldonado, “Genetic analysis of drug addiction: the role of cAMP response element binding protein,” Journal of Molecular Medicine, vol. 76, no. 2, pp. 104–110, 1998. View at Publisher · View at Google Scholar · View at Scopus
  6. E. J. Nestler, “Is there a common molecular pathway for addiction?” Nature Neuroscience, vol. 8, no. 11, pp. 1445–1449, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. D. B. Beitner, R. S. Duman, and E. J. Nestler, “A novel action of morphine in the rat locus coeruleus: persistent decrease in adenylate cyclase,” Molecular Pharmacology, vol. 35, no. 5, pp. 559–564, 1989. View at Scopus
  8. R. S. Duman, J. F. Tallman, and E. J. Nestler, “Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus,” Journal of Pharmacology and Experimental Therapeutics, vol. 246, no. 3, pp. 1033–1039, 1988. View at Scopus
  9. E. J. Nestler and G. K. Aghajanian, “Molecular and cellular basis of addiction,” Science, vol. 278, no. 5335, pp. 58–63, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. K. L. Widnell, J.-S. Chen, P. A. Iredale et al., “Transcriptional regulation of CREB (cyclic AMP response element-binding protein) expression in CATH.a cells,” Journal of Neurochemistry, vol. 66, no. 4, pp. 1770–1773, 1996. View at Scopus
  11. K. Iijima, L. Zhao, C. Shenton, and K. Iijima-Ando, “Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila,” PLoS ONE, vol. 4, no. 12, Article ID e8498, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. D. Georgescu, R. M. Sears, J. D. Hommel et al., “The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance,” Journal of Neuroscience, vol. 25, no. 11, pp. 2933–2940, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. M. Shimizu-Albergine, D. L. Ippolito, and J. A. Beavo, “Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus,” Journal of Neuroscience, vol. 21, no. 4, pp. 1238–1246, 2001. View at Scopus
  14. G. M. Sutton, B. Duos, L. M. Patterson, and H.-R. Berthoud, “Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through ERK signaling in rat solitary nucleus,” Endocrinology, vol. 146, no. 9, pp. 3739–3747, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. G. Li, C. V. Mobbs, and P. J. Scarpace, “Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats,” Diabetes, vol. 52, no. 8, pp. 1951–1957, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. V. G. Olson, T. A. Green, R. L. Neve, and E. J. Nestler, “Regulation of morphine reward and feeding by CREB in the lateral hypothalamus,” Synapse, vol. 61, no. 2, pp. 110–113, 2007. View at Publisher · View at Google Scholar · View at Scopus
  17. P. Marquez, R. Baliram, N. Gajawada, T. C. Friedman, and K. Lutfy, “Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine,” Behavioral Neuroscience, vol. 120, no. 1, pp. 10–15, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. P. Marquez, R. Baliram, I. Dabaja, N. Gajawada, and K. Lutfy, “The role of beta-endorphin in the acute motor stimulatory and rewarding actions of cocaine in mice,” Psychopharmacology, vol. 197, no. 3, pp. 443–448, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. E. L. Way, H. H. Loh, and F. H. Shen, “Simultaneous quantitative assessment of morphine tolerance and physical dependence,” Journal of Pharmacology and Experimental Therapeutics, vol. 167, no. 1, pp. 1–8, 1969. View at Scopus
  20. K. Lutfy, S. M. Hossain, I. Khaliq, and N. T. Maidment, “Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats,” British Journal of Pharmacology, vol. 134, no. 3, pp. 529–534, 2001. View at Scopus
  21. S. J. Cooper and D. J. Sanger, “Endorphinergic mechanisms in food, salt and water intake: an overview,” Appetite, vol. 5, no. 1, pp. 1–6, 1984. View at Scopus
  22. L. Grandison and A. Guidotti, “Stimulation of food intake by muscimol and beta endorphin,” Neuropharmacology, vol. 16, no. 7-8, pp. 533–536, 1977. View at Scopus
  23. J. E. Morley, A. S. Levine, B. A. Gosnell, and C. J. Billington, “Which opioid receptor mechanism modulates feeding?” Appetite, vol. 5, no. 1, pp. 61–68, 1984. View at Scopus
  24. S. J. Cooper, “Behaviourally-specific hyperdipsia in the non-deprived rat following acute morphine treatment,” Neuropharmacology, vol. 20, no. 5, pp. 469–472, 1981. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Frenk and G. H. Rogers, “The suppressant effects of naloxone on food and waterintake in the rat,” Behavioral and Neural Biology, vol. 26, no. 1, pp. 23–40, 1979. View at Scopus
  26. M. Kunihara, M. Kanbayashi, and T. Ohshima, “Opposite effects of morphine on feeding and drinking in rats relative to administration time,” Japanese Journal of Pharmacology, vol. 33, no. 4, pp. 829–835, 1983. View at Scopus
  27. M. Leshem, “Morphine-induced anorexia in lateral hypothalamic rats,” Psychopharmacology, vol. 75, no. 1, pp. 48–53, 1981. View at Scopus
  28. R. Marks-Kaufman and R. B. Kanarek, “Morphine selectively influences macronutrient intake in the rat,” Pharmacology Biochemistry and Behavior, vol. 12, no. 3, pp. 427–430, 1980. View at Publisher · View at Google Scholar · View at Scopus
  29. D. J. Sanger and P. S. McCarthy, “Differential effects of morphine on food and water intake in food deprived and freely-feeding rats,” Psychopharmacology, vol. 72, no. 1, pp. 103–106, 1980. View at Scopus
  30. D. L. Wolgin and H. D. Benson, “Role of associative and nonassociative mechanisms in tolerance to morphine 'anorexia',” Pharmacology Biochemistry and Behavior, vol. 39, no. 2, pp. 279–286, 1991. View at Scopus
  31. A. S. Levine, J. E. Morley, B. A. Gosnell, C. J. Billington, and T. J. Bartness, “Opioids and consummatory behavior,” Brain Research Bulletin, vol. 14, no. 6, pp. 663–672, 1985. View at Publisher · View at Google Scholar · View at Scopus
  32. M. Leshem, “Morphine induces delayed anorexia in rats,” Psychopharmacology, vol. 94, no. 2, pp. 254–258, 1988. View at Scopus
  33. R. L. Atkinson, “Opioid regulation of food intake and body weight in humans,” Federation Proceedings, vol. 46, no. 1, pp. 178–182, 1987. View at Scopus
  34. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman, “Correction: Positional cloning of the mouse obese gene and its human homologue,” Nature, vol. 374, no. 6521, pp. 425–432, 1995. View at Scopus
  35. E. J. Nestler, “Molecular mechanisms of drug addiction,” Neuropharmacology, vol. 47, supplement 1, pp. 24–32, 2004. View at Publisher · View at Google Scholar · View at Scopus
  36. G. C. Harris, M. Wimmer, and G. Aston-Jones, “A role for lateral hypothalamic orexin neurons in reward seeking,” Nature, vol. 437, no. 7058, pp. 556–559, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. B. Boutrel, P. J. Kenny, S. E. Specio et al., “Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 52, pp. 19168–19173, 2005. View at Publisher · View at Google Scholar · View at Scopus
  38. E. Jansen, T. A. Y. Ayoubi, S. M. P. Meulemans, and W. J. M. Van de Ven, “Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements,” The Journal of Biological Chemistry, vol. 270, no. 25, pp. 15391–15397, 1995. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Jansen, T. A. Y. Ayoubi, S. M. P. Meulemans, and W. J. M. Van De Ven, “Regulation of human prohormone convertase 2 promoter activity by the transcription factor EGR-1,” Biochemical Journal, vol. 328, no. 1, pp. 69–74, 1997. View at Scopus
  40. V. P. Espinosa, Y. Liu, M. Ferrini et al., “Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the “switch” to opiate addiction,” Neuroscience, vol. 156, no. 3, pp. 788–799, 2008. View at Publisher · View at Google Scholar · View at Scopus
  41. A. Anghel, C. A. M. Jamieson, X. Ren et al., “Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake,” Neuroscience, vol. 167, no. 2, pp. 554–566, 2010. View at Publisher · View at Google Scholar · View at Scopus