- About this Journal ·
- Abstracting and Indexing ·
- Aims and Scope ·
- Article Processing Charges ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Recently Accepted Articles ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
Journal of Obesity
Volume 2013 (2013), Article ID 764742, 11 pages
Alterations in Phosphorylated CREB Expression in Different Brain Regions following Short- and Long-Term Morphine Exposure: Relationship to Food Intake
1Division of Endocrinology, Metabolism and Molecular Medicine, Department of Medicine, Charles R. Drew University of Medicine and Science and UCLA School of Medicine, 1731 E. 120th. Street, Los Angeles, CA 90059, USA
2Department of Pediatrics, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA 90027, USA
3College of Pharmacy, Western University of Health Sciences, Pomona, CA 91766, USA
Received 20 June 2013; Accepted 19 July 2013
Academic Editor: Yvon Chagnon
Copyright © 2013 Xiuhai Ren et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- E. J. Nestler, “Molecular mechanisms of opiate and cocaine addiction,” Current Opinion in Neurobiology, vol. 7, no. 5, pp. 713–719, 1997.
- X. Guitart, M. A. Thompson, C. K. Mirante, M. E. Greenberg, and E. J. Nestler, “Regulation of cyclic AMP response element-binding protein (CREB) phosphorylation by acute and chronic morphine in the rat locus coeruleus,” Journal of Neurochemistry, vol. 58, no. 3, pp. 1168–1171, 1992.
- S. B. Lane-Ladd, J. Pineda, V. A. Boundy et al., “CREB (cAMP response element-binding protein) in the locus coeruleus: biochemical, physiological, and behavioral evidence for a role in opiate dependence,” Journal of Neuroscience, vol. 17, no. 20, pp. 7890–7901, 1997.
- J. A. Blendy, K. H. Kaestner, W. Schmid, P. Gass, and G. Schütz, “Targeting of the CREB gene leads to up-regulation of a novel CREB mRNA isoform,” EMBO Journal, vol. 15, no. 5, pp. 1098–1106, 1996.
- J. A. Blendy and R. Maldonado, “Genetic analysis of drug addiction: the role of cAMP response element binding protein,” Journal of Molecular Medicine, vol. 76, no. 2, pp. 104–110, 1998.
- E. J. Nestler, “Is there a common molecular pathway for addiction?” Nature Neuroscience, vol. 8, no. 11, pp. 1445–1449, 2005.
- D. B. Beitner, R. S. Duman, and E. J. Nestler, “A novel action of morphine in the rat locus coeruleus: persistent decrease in adenylate cyclase,” Molecular Pharmacology, vol. 35, no. 5, pp. 559–564, 1989.
- R. S. Duman, J. F. Tallman, and E. J. Nestler, “Acute and chronic opiate-regulation of adenylate cyclase in brain: specific effects in locus coeruleus,” Journal of Pharmacology and Experimental Therapeutics, vol. 246, no. 3, pp. 1033–1039, 1988.
- E. J. Nestler and G. K. Aghajanian, “Molecular and cellular basis of addiction,” Science, vol. 278, no. 5335, pp. 58–63, 1997.
- K. L. Widnell, J.-S. Chen, P. A. Iredale et al., “Transcriptional regulation of CREB (cyclic AMP response element-binding protein) expression in CATH.a cells,” Journal of Neurochemistry, vol. 66, no. 4, pp. 1770–1773, 1996.
- K. Iijima, L. Zhao, C. Shenton, and K. Iijima-Ando, “Regulation of energy stores and feeding by neuronal and peripheral CREB activity in Drosophila,” PLoS ONE, vol. 4, no. 12, Article ID e8498, 2009.
- D. Georgescu, R. M. Sears, J. D. Hommel et al., “The hypothalamic neuropeptide melanin-concentrating hormone acts in the nucleus accumbens to modulate feeding behavior and forced-swim performance,” Journal of Neuroscience, vol. 25, no. 11, pp. 2933–2940, 2005.
- M. Shimizu-Albergine, D. L. Ippolito, and J. A. Beavo, “Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus,” Journal of Neuroscience, vol. 21, no. 4, pp. 1238–1246, 2001.
- G. M. Sutton, B. Duos, L. M. Patterson, and H.-R. Berthoud, “Melanocortinergic modulation of cholecystokinin-induced suppression of feeding through ERK signaling in rat solitary nucleus,” Endocrinology, vol. 146, no. 9, pp. 3739–3747, 2005.
- G. Li, C. V. Mobbs, and P. J. Scarpace, “Central pro-opiomelanocortin gene delivery results in hypophagia, reduced visceral adiposity, and improved insulin sensitivity in genetically obese Zucker rats,” Diabetes, vol. 52, no. 8, pp. 1951–1957, 2003.
- V. G. Olson, T. A. Green, R. L. Neve, and E. J. Nestler, “Regulation of morphine reward and feeding by CREB in the lateral hypothalamus,” Synapse, vol. 61, no. 2, pp. 110–113, 2007.
- P. Marquez, R. Baliram, N. Gajawada, T. C. Friedman, and K. Lutfy, “Differential involvement of enkephalins in analgesic tolerance, locomotor sensitization, and conditioned place preference induced by morphine,” Behavioral Neuroscience, vol. 120, no. 1, pp. 10–15, 2006.
- P. Marquez, R. Baliram, I. Dabaja, N. Gajawada, and K. Lutfy, “The role of beta-endorphin in the acute motor stimulatory and rewarding actions of cocaine in mice,” Psychopharmacology, vol. 197, no. 3, pp. 443–448, 2008.
- E. L. Way, H. H. Loh, and F. H. Shen, “Simultaneous quantitative assessment of morphine tolerance and physical dependence,” Journal of Pharmacology and Experimental Therapeutics, vol. 167, no. 1, pp. 1–8, 1969.
- K. Lutfy, S. M. Hossain, I. Khaliq, and N. T. Maidment, “Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats,” British Journal of Pharmacology, vol. 134, no. 3, pp. 529–534, 2001.
- S. J. Cooper and D. J. Sanger, “Endorphinergic mechanisms in food, salt and water intake: an overview,” Appetite, vol. 5, no. 1, pp. 1–6, 1984.
- L. Grandison and A. Guidotti, “Stimulation of food intake by muscimol and beta endorphin,” Neuropharmacology, vol. 16, no. 7-8, pp. 533–536, 1977.
- J. E. Morley, A. S. Levine, B. A. Gosnell, and C. J. Billington, “Which opioid receptor mechanism modulates feeding?” Appetite, vol. 5, no. 1, pp. 61–68, 1984.
- S. J. Cooper, “Behaviourally-specific hyperdipsia in the non-deprived rat following acute morphine treatment,” Neuropharmacology, vol. 20, no. 5, pp. 469–472, 1981.
- H. Frenk and G. H. Rogers, “The suppressant effects of naloxone on food and waterintake in the rat,” Behavioral and Neural Biology, vol. 26, no. 1, pp. 23–40, 1979.
- M. Kunihara, M. Kanbayashi, and T. Ohshima, “Opposite effects of morphine on feeding and drinking in rats relative to administration time,” Japanese Journal of Pharmacology, vol. 33, no. 4, pp. 829–835, 1983.
- M. Leshem, “Morphine-induced anorexia in lateral hypothalamic rats,” Psychopharmacology, vol. 75, no. 1, pp. 48–53, 1981.
- R. Marks-Kaufman and R. B. Kanarek, “Morphine selectively influences macronutrient intake in the rat,” Pharmacology Biochemistry and Behavior, vol. 12, no. 3, pp. 427–430, 1980.
- D. J. Sanger and P. S. McCarthy, “Differential effects of morphine on food and water intake in food deprived and freely-feeding rats,” Psychopharmacology, vol. 72, no. 1, pp. 103–106, 1980.
- D. L. Wolgin and H. D. Benson, “Role of associative and nonassociative mechanisms in tolerance to morphine 'anorexia',” Pharmacology Biochemistry and Behavior, vol. 39, no. 2, pp. 279–286, 1991.
- A. S. Levine, J. E. Morley, B. A. Gosnell, C. J. Billington, and T. J. Bartness, “Opioids and consummatory behavior,” Brain Research Bulletin, vol. 14, no. 6, pp. 663–672, 1985.
- M. Leshem, “Morphine induces delayed anorexia in rats,” Psychopharmacology, vol. 94, no. 2, pp. 254–258, 1988.
- R. L. Atkinson, “Opioid regulation of food intake and body weight in humans,” Federation Proceedings, vol. 46, no. 1, pp. 178–182, 1987.
- Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman, “Correction: Positional cloning of the mouse obese gene and its human homologue,” Nature, vol. 374, no. 6521, pp. 425–432, 1995.
- E. J. Nestler, “Molecular mechanisms of drug addiction,” Neuropharmacology, vol. 47, supplement 1, pp. 24–32, 2004.
- G. C. Harris, M. Wimmer, and G. Aston-Jones, “A role for lateral hypothalamic orexin neurons in reward seeking,” Nature, vol. 437, no. 7058, pp. 556–559, 2005.
- B. Boutrel, P. J. Kenny, S. E. Specio et al., “Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 52, pp. 19168–19173, 2005.
- E. Jansen, T. A. Y. Ayoubi, S. M. P. Meulemans, and W. J. M. Van de Ven, “Neuroendocrine-specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements,” The Journal of Biological Chemistry, vol. 270, no. 25, pp. 15391–15397, 1995.
- E. Jansen, T. A. Y. Ayoubi, S. M. P. Meulemans, and W. J. M. Van De Ven, “Regulation of human prohormone convertase 2 promoter activity by the transcription factor EGR-1,” Biochemical Journal, vol. 328, no. 1, pp. 69–74, 1997.
- V. P. Espinosa, Y. Liu, M. Ferrini et al., “Differential regulation of prohormone convertase 1/3, prohormone convertase 2 and phosphorylated cyclic-AMP-response element binding protein by short-term and long-term morphine treatment: implications for understanding the “switch” to opiate addiction,” Neuroscience, vol. 156, no. 3, pp. 788–799, 2008.
- A. Anghel, C. A. M. Jamieson, X. Ren et al., “Gene expression profiling following short-term and long-term morphine exposure in mice uncovers genes involved in food intake,” Neuroscience, vol. 167, no. 2, pp. 554–566, 2010.