Review Article
Bariatric Surgery as Potential Treatment for Nonalcoholic Fatty Liver Disease: A Future Treatment by Choice or by Chance?
Table 1
Considerable studies showed that RYGB is associated with marked improvement in NAFLD.
| Roux-en-Y | Study | Ref | Main outcomes | Type of study | Sample size | Followup |
| Silverman et al., 1995 | [20] | Improved steatosis and fibrosis | Retrospective cohort | 91 | 18.4 months | Clark et al., 2005 | [21] | Improved steatosis, fibrosis, and inflammation | Prospective cohort | 16 | 305 ± 131 days | Mattar et al., 2005 | [22] | Improved metabolic syndrome, steatosis, and fibrosis | Prospective cohort | 70 | 15 ± 9 months | Mottin et al., 2005 | [23] | 82% improvement in liver steatosis and fibrosis not measured | Retrospective cohort | 90 | 12 months | Klein et al., 2006 | [24] | Decreased factors lead to liver fibrosis and inflammation | Prospective cohort | 7 | 12 months | Barker et al., 2006 | [25] | Improved histology of NAFLD | Prospective cohort | 19 | 21.4 months | Csendes et al., 2006 | [26] | Improved histology in 80% | Prospective cohort | 16 | 22 months | de Almeida et al., 2006 | [27] | Improved steatosis, fibrosis, and inflammation | Prospective cohort | 16 | 23.5 ± 8.4 months | Furuya et al., 2007 | [28] | Improved steatosis and fibrosis | Prospective cohort | 18 | 24 months | Liu et al., 2007 | [29] | Resolved NASH in 60% | Retrospective cohort | 39 | 18 months | Weiner 2010 | [30] | Complete regression of NAFLD in 83% | Retrospective cohort | 116 | 18.6 ± 8.3 months | Moretto et al., 2012 | [31] | Resolved fibrosis in 50% | Retrospective cohort | 78 | Unavailable |
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