Complement Receptors C5aR and C5L2 Are Associated with Metabolic Profile, Sex Hormones, and Liver Enzymes in Obese Women Pre- and Postbariatric Surgery
Figure 4
Metabolic profile after surgery. mRNA was extracted from liver biopsies and reverse-transcribed to cDNA and gene expression was evaluated by RT-PCR with the indicated primers with all results expressed relative to GAPDH using the method as described in detail in Section 2. (a) Linear correlation plot of liver C5L2 mRNA expression at time of surgery versus % weight loss 12 months after surgery, analyzed by Pearson correlation test. (b) Percentage changes of metabolic profile before and after bariatric surgery and categorical comparisons between the high and low C5L2/C5aR mRNA ratio subgroups, analyzed by Fisher exact test. BMI: body mass index; GLU: fasting glucose; HDL-C: high density lipoprotein-cholesterol; LDL-C: low density lipoprotein-cholesterol; TG: triglyceride; TC: total cholesterol.
