The Intrauterine and Nursing Period Is a Window of Susceptibility for Development of Obesity and Intestinal Tumorigenesis by a High Fat Diet in Min/+ Mice as Adults
Table 2
Effects of exposure to a 45% fat diet during various periods of life on absolute liver weight (ALW), relative liver weight (RLW), absolute spleen weight (ASW), and relative spleen weight (RSW) in female and male wild-type mice terminated at 23 weeks of age (mean of individual mice in the group ± SD).
Experimental group
n
BW (g)
ALW (g)
RLW (%)
ASW (g)
RSW (%)
+/+, females
10 + 10 + 10
26
25.9 ± 3.3
1.03 ± 0.34
0.12 ± 0.03
45 + 10 + 10
24
26.8 ± 4.2
1.03 ± 0.32
3.79 ± 0.85b
0.11 ± 0.03
0.41 ± 0.12
10 + 45 + 10
21
28.0 ± 3.9
1.15 ± 0.38
0.14 ± 0.09a
45 + 45 + 10
31
27.6 ± 3.9
1.08 ± 0.35
0.11 ± 0.03
0.42 ± 0.14
10 + 10 + 45
26
31.3 ± 6.2
1.02 ± 0.22
0.10 ± 0.02a
45 + 45 + 45
31
34.3 ± 4.0
1.04 ± 0.23
0.11 ± 0.02
45 + 45 + 10 PhIP
21
27.0 ± 3.6
1.11 ± 0.34
4.06 ± 0.87
0.12 ± 0.03
0.43 ± 0.13
45 + 45 + 45 PhIP
21
33.9 ± 7.5
1.05 ± 0.32
3.09 ± 0.66
0.11 ± 0.02
0.34 ± 0.11
+/+, males
10 + 10 + 10
25
35.0 ± 5.1
1.43 ± 0.41a
4.02 ± 0.75
0.11 ± 0.02
0.34 ± 0.11
45 + 10 + 10
36
36.0 ± 4.3
1.54 ± 0.26
4.28 ± 0.53
0.11 ± 0.02
0.30 ± 0.07
10 + 45 + 10
24
37.2 ± 4.2
1.42 ± 0.24b
3.81 ± 0.47
0.11 ± 0.02
0.30 ± 0.07
45 + 45 + 10
27
36.4 ± 5.6
1.51 ± 0.37
4.18 ± 0.90
0.10 ± 0.03
0.29 ± 0.09
10 + 10 + 45
27
40.5 ± 7.5
1.54 ± 0.53
3.75 ± 0.83
0.10 ± 0.02
0.25 ± 0.07
45 + 45 + 45
46
42.9 ± 5.8
3.95 ± 0.98
0.12 ± 0.02
0.28 ± 0.08
45 + 45 + 10 PhIP
25
38.5 ± 4.1
1.49 ± 0.30
3.84 ± 0.47
0.12 ± 0.04
0.32 ± 0.15
45 + 45 + 45 PhIP
28
44.6 ± 5.0
1.70 ± 0.47
3.76 ± 0.74
0.11 ± 0.02
0.24 ± 0.05
Relative liver weight (RLW) (%) = absolute liver weight (ALW)/body weight (BW) × 100, relative spleen weight (RSW) (%) = absolute spleen weight (ASW)/BW × 100. g = gram. Dietary treatment groups within each gender with similar letters are significantly different.
