Journal of Obesity

Research Article

Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats

Table 1

Biochemical results of the diabetes rats and controls.


Group	Glu (mg/dl)	TG (mg/dl)	TC (mg/dl)	LDL (mg/dl)	HDL (mg/dl)	VLDL (mg/dl)

Control (C)	156.50 ± 11.80^###	79.83 ± 3.19^+++#	61.67 ± 2.22^+##	18.67 ± 2.22	34.33 ± 1.89	7.55 ± 0.58^###
Sham (D)	317.00 ± 18.01⁺⁺⁺	101.33 ± 5.50⁺⁺⁺	78.83 ± 3.18⁺⁺⁺	22.67 ± 1.33⁺⁺	28.50 ± 1.75⁺⁺⁺	23.00 ± 1.53⁺⁺⁺
Met	161.00 ± 18.88^###	36.67 ± 2.65^###	48.50 ± 3.92^###	15.50 ± 1.15^##	44.33 ± 2.50^###	7.62 ± 0.70^###
C25	173.83 ± 16.09^###	81.33 ± 6.16⁺⁺⁺	57.83 ± 2.61^###	16.17 ± 0.54^#	53.17 ± 4.80^###	14.60 ± 0.61^###+++
C50	232.00 ± 26.97	87.17 ± 2.68⁺⁺⁺	71.50 ± 2.17⁺⁺⁺	18.83 ± 1.25	60.83 ± 1.08^###+++	16.33 ± 1.22^###+++
C100	191.17 ± 15.37^###	67.67 ± 5.23^+++###	66.50 ± 1.95⁺⁺⁺	16.83 ± 1.30^#	52.5 ± 2.03^###	12.38 ± 0.73^###++
D25	207.67 ± 13.53^##	37.00 ± 2.66^###	58.00 ± 2.35^###	18.50 ± 1.26	44.0 ± 1.37^##	7.80 ± 0.60^###
D50	233.00 ± 20.23	38.00 ± 2.79^###	65.83 ± 3.46^#++	18.67 ± 0.33	47.67 ± 2.08^###	7.32 ± 0.52^###
D100	205.50 ± 29.34^##	64.83 ± 8.09^++###	68.17 ± 2.83⁺⁺⁺	17.00 ± 0.86^#	45.83 ± 2.52^###	13.03 ± 0.80^###++

Values are presented as mean ± SEM(n = 6/each group).Statistically different from the control rats (), statistically different from the control rats (c), statistically different from the control rats (), ^#statistically different from the sham rats (), ^##statistically different from the sham rats (), ^###statistically different from the sham rats (), ⁺Statistically different from the Met rats (), ⁺⁺statistically different from the Met rats (), ⁺⁺⁺statistically different from the Met rats (). The sham (D): diabetic rats, MET: diabetic rats + metformin(55 mg/kg), C25: control rats + p-cymene (25 mg/kg), C50: control rats + p-cymene (50 mg/kg), C100: control rats + p-cymene (100 mg/kg), D25: diabetic rats + p-cymene (25 mg/kg), D50: diabetic rats + p-cymene (50 mg/kg), D100: diabetic rats + p-cymene (100 mg/kg). TG: Triglyceride, TC: Total Cholesterol, LDL: low-density lipoprotein, HDL: high-density lipoprotein, VLDL: very low-density lipoproteins.