| Parameter | Lipedema group (n = 28) mean ± SD/me (Q1, Q3) | Overweight/obesity group (n = 24) mean ± SD/me (Q1, Q3) | Differences between baseline and 7 months mean ± SD/me (Q1, Q3) | Baseline | 7 months | values | Baseline | 7 months | values | Lipedema | Overweight/obesity | t/Z | values |
| Weight (kg) | 83.8 (76.9, 93.3) | 73.4 (64.4, 83.2) | ≤0.001 | 91.9 (79.8, 97.8) | 77.1 (67.2, 86.5) | <0.001 | −10.8 (6.4, 14.5) | −11.9 (10.5, 13.8) | 1.49 | 0.14^ | BMI (kg/m2) | 31.4 ± 6.2 | 27.3 ± 5.1 | ≤0.001 | 34.1 ± 4.6 | 29.3 ± 4.0 | ≤0.001 | −4.1 ± 2.5 | −4.8 ± 1.8 | 1.55 | 0.12^ | LBM (kg) | 51.2 ± 6.8 | 48.7 ± 5.6 | <0.001 | 52.4 ± 7.2 | 49.7 ± 6.9 | <0.001 | −2.5 ± 2.5 | −2.7 ± 3.0 | 0.74 | 0.74 | PBF (%) | 39.9 (35.7, 42.8) | 33.8 (27.8, 37.4) | <0.001 | 40.5 (36.8, 43.6) | 33.2 (28.9, 39.3) | <0.001 | −6.0 (3.4, 8.3) | −6.3 (4.5, 8.4) | 0.57 | 0.57^ | MBF (kg) | 33.6 (28.4, 39.2) | 25.2 (18.8, 30.2) | <0.001 | 36.7 (29.3, 43.1) | 25.5 (20.0, 34.5) | <0.001 | −7.4 (5.5, 12.7) | −9.3 (7.2, 11.9) | 1.33 | 0.18^ | TBW (kg) | 38.4 ± 5.5 | 37.6 ± 6.3 | 0.12 | 39.1 ± 5.5 | 37.0 ± 5.3 | <0.001 | −0.9 ± 2.8 | −2.1 ± 2.3 | 1.72 | 0.09 | VFL | 14.0 (8.5, 16.5) | 9.5 (4.0, 12.0) | <0.001 | 10.5 (8.0, 13.5) | 8.0 (6.0, 10.0) | <0.001∗∗ | −3.0 (2.0, 5.0) | −3.0 (2.0, 3.0) | −0.95 | 0.35^ | Waist (cm) | 97.8 ± 12.8 | 86 ± 11.4 | ≤0.001 | 106.5 ± 10.6 | 94.1 ± 11.8 | ≤0.001 | −11.7 ± 6.6 | −12.4 ± 6.3 | 0.38 | 0.71 | Hips (cm) | 115.3 (106.5, 122.0) | 107.0 (98.0, 111.8) | <0.001 | 114.5 (108.5, 120.0) | 104.3 (100.5, 108.3) | <0.001 | −8.5 (6.3, 11.8) | −8.8 (7.3, 11.5) | 0.6 | 0.55^ | WHR | 0.8 ± 0.1 | 0.8 ± 0.1 | <0.001 | 0.9 ± 0.1 | 0.9 ± 0.1 | 0.02 | 0.0 ± 0.0 | 0.0 ± 0.1 | −0.43 | 0.67 | Left thigh (cm) | 65.0 ± 7.0 | 59.2 ± 5.6 | ≤0.001 | 64.8 ± 5.7 | 59.0 ± 5.3 | ≤0.001 | −5.9 ± 3.1 | −5.9 ± 2.2 | −0.03 | 0.98 | Right thigh (cm) | 64.9 ± 6.9 | 58.9 ± 5.6 | ≤0.001 | 64.9 ± 5.9 | 59.0 ± 5.5 | ≤0.001 | −5.9 ± 3.3 | −5.9 ± 2.4 | −0.09 | 0.93 | Left calf (cm) | 44.0 (40.3, 46.5) | 40.3 (37.5, 43.0) | <0.001 | 42.0 (40.3, 44.0) | 39.3 (37.5, 41.3) | <0.001 | −3.5 (2.8, 4.8) | −2.8 (1.8, 4.0) | −1.8 | 0.07^ | Right calf (cm) | 44.3 (40.3, 47.0) | 41.3 (37.8, 43.0) | <0.001 | 42.3 (39.3, 44.8) | 39.5 (37.5, 41.0) | <0.001 | −3.0 (2.0, 4.5) | −2.5 (1.8, 3.3) | −1.56 | 0.12^ | Left ankle (cm) | 24.5 (23.5, 26.0) | 23.8 (22.5, 25.0) | <0.001 | 23.0 (22.0, 24.5) | 23.0 (22.3, 24.0) | 0.09 | −1.0 (0.5, 1.5) | −0.5 (0.0, 0.5) | −3.2 | <0.01^ | Right ankle (cm) | 24.0 (23.5, 26.0) | 23.3 (22.5, 24.8) | <0.001 | 23.3 (22.3, 24.5) | 23.0 (22.2, 24.0) | 0.04 | −1.0 (0.5, 1.8) | −0.5 (0.0, 0.8) | −2.72 | <0.01^ | Left leg VOL (ml) | 11216.5 (10110.0, 14152.0) | 9707.5 (8785.0, 11849.8) | <0.001 | 10946.0 (8840.0, 12576.0) | 8725.5 (7421.0, 10524.0) | <0.001 | −1395.5 (811.5, 2614.0) | −1443.2 (1066.0, 2057.5) | −0.09 | 0.93^ | Right leg VOL (ml) | 11910.5 (10208.5, 14259.0) | 10063.0 (8543.5, 12556.5) | <0.001 | 11239.0 (8991.0, 12185.0) | 9503.8 (7578.0, 10892.0) | <0.001 | −1524.0 (865.0, 2357.5) | −1487.5 (1031.5, 1961.5) | −0.07 | 0.94^ | VAS | 4.6 ± 2.6 | 3.0 ± 2.3 | <0.001 | — | — | — | — | — | — | — |
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