The Interplay between Adipose Tissue Properties and Levels of NT-proBNP in People with HIV

Table 2

Associations of adipose tissue measurements with low concentrations of NT-proBNP.

Adipose tissue measurement	Base model		Adjusted model		Adjusted for LAVi
	OR [95% CI]	value	OR [95% CI]	value	OR [95% CI]	value
BMI, per 1 kg/m^2 increase	1.06 [1.02; 1.10]	0.004	1.06 [1.01; 1.11]	0.009	1.07 [1.01; 1.14]	0.02
Central obesity	1.52 [1.10; 2.10]	0.01	1.66 [1.16; 2.36]	0.005	1.72 [1.14; 2.60]	0.01
Large VAT area	1.38 [0.92; 2.06]	0.12	1.69 [1.09; 2.62]	0.02	1.58 [0.95; 2.62]	0.08
Large SAT area	1.09 [0.69; 1.71]	0.71	1.24 [0.76; 2.01]	0.39	1.07 [0.60; 1.90]	0.82
Adiponectin, per 10% increase	0.87 [0.80; 0.96]	0.004	0.86 [0.79; 0.95]	0.003	0.86 [0.76; 0.96]	0.008

BMI, body mass index; VAT, visceral adipose tissue; SAT, subcutaneous adipose tissue; LAVi, left atrial volume index. Values shown are odds ratios (95% CI) for having low concentrations of NT-proBNP adjusted for age and sex (base model) and after further adjustment for diabetes, hypertension, eGFR, HCV-antibodies (adjusted model) and LAVi. Additionally, models exploring associations between VAT, SAT, and adiponectin and low NT-proBNP were adjusted for BMI. Large VAT and SAT areas were ascribed PWH with areas in the upper quartile (≥141.1 cm² and ≥184.8 cm², respectively). 684 PWH were included in the adjusted model exploring associations between low NT-proBNP and BMI, central obesity as well as large VAT and SAT areas (538 when further adjusting for LAVi), while 593 were included in the adjusted model exploring associations between low NT-proBNP and adiponectin (467 when further adjusting for LAVi).