Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan
Table 1
The demographic data of NAFLD and control subjects.
Variables
NW (n = 34)
OW (n = 38)
OB (n = 31)
HS (n = 50)
value
Gender (M/F)
17/17
14/24
6/25
21/29
0.467NS
Age (years, mean ± SD)
38 ± 11
41 ± 9
43 ± 9
27 ± 11
<0.001
History of NAFLD (yes/no)
4/30
5/33
6/25
0/50
0.004
Exercise (yes/no)
18/16
26/12
18/13
32/18
0.650NS
Smoking (yes/no)
3/31
2/36
2/29
0/50
0.059NS
Diabetes (yes/no)
9/25
15/23
12/19
0/50
<0.001
Hypertension (yes/no)
4/30
10/28
9/22
0/50
<0.001
NAFLD duration (weeks, mean ± SD)
44 ± 121
103 ± 183
95 ± 186
0.000 ± 0.000
0.033
BMI (kg/m2, mean ± SD)
22.27 ± 1.73
27.15 ± 1.37
33.47 ± 3.14
20.82 ± 2.79
<0.001
Fat content (%, mean ± SD)
25.20 ± 6.12
32.76 ± 5.97
42.64 ± 7.02
21.53 ± 5.23
<0.001
Blood pressure (systolic/diastolic) (mmHg, mean ± SD)
120 ± 6/80 ± 5
123 ± 11/83 ± 9
122 ± 7/82 ± 7
120 ± 0/80 ± 0
<0.001
GCKR (rs1260326) (CC/TT/CT)
18/7/9
19/6/13
18/3/10
9/7/34
<0.001
NW: normal weight (BMI >18.5 to <25), OW: overweight (BMI 25 to<30), OB: obese (BMI >30), HS: healthy subjects, data are presented as mean ± SD, Chi-square test was used, and ,, and . Bold values indicate significantly associated risk factor with disease progression.
