Prevalence of GCKR rs1260326 Variant in Subjects with Obesity Associated NAFLD and T2DM: A Case-Control Study in South Punjab, Pakistan
Table 2
The demographic data of T2DM and control subjects.
Variables
NW (n = 30)
OW (n = 27)
OB (n = 43)
HS (n = 50)
value
Gender (M/F)
18/12
17/10
10/33
47/3
<0.001
Age (years, mean ± SD)
52 ± 10
51 ± 9
51 ± 9
51 ± 10
0.588NS
Marital (yes/no)
26/4
25/2
40/3
43/7
0.350NS
Smoking (yes/no)
8/22
5/22
9/34
6/44
0.138NS
Family history (yes/no)
13/17
17/10
30/13
11/39
<0.001
Exercise (yes/no)
19/11
12/15
16/27
40/10
<0.001
Waist (In., mean ± SD)
38 ± 36
41.59 ± 3.09
45.72 ± 2.67
35.66 ± 3.08
<0.001
BMI (kg/m2, mean ± SD)
22.24 ± 2.24
27.21 ± 1.35
33.44 ± 2.42
23.44 ± 3.35
<0.001
Fat content (%, mean ± SD)
27.19 ± 6.78
32.72 ± 5.39
44.09 ± 5.03
24.25 ± 5.16
<0.001
Blood pressure (systolic/diastolic) (mmHg, mean ± SD)
137 ± 24/88 ± 10
151 ± 35/94 ± 17
146 ± 43/94 ± 30
131 ± 27/87 ± 13
0.659NS/0.172NS
FBGL (mg/dl, mean ± SD)
191.78 ± 41.97
188.33 ± 35.45
196.44 ± 47.55
66.96 ± 9.87
<0.001
RBGL (mg/dl, mean ± SD)
360.56 ± 72.92
248.14 ± 63.73
369.01 ± 71.51
124.54 ± 15.34
<0.001
HbA1c (%, mean ± SD)
9.45 ± 1.38
9.23 ± 1.33
9.72 ± 1.62
3.92 ± 0.33
<0.001
GCKR (rs1260326) (CC/TT/CT)
15/9/6
18/5/4
20/11/12
11/29/10
<0.001
Data are presented as mean ± SD; FBGL (fasting blood glucose level); RBGL (random blood glucose level); HbA1c (haemoglobin A1C). Chi-square test was used and ,, and . Bold values indicate significantly associated risk factor with disease progression.
