Journal of Obesity

Research Article

The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants

Table 1

The levels of adipokines, myokines, hormones, and biochemical indices in the blood of healthy and obese boys with different genotypes for LPL (rs328).
IndexControl group (healthy boys)Subject group (boys with obesity)
GenotypeSer447Ser447TerSer447Ser447Ter
SDS BMI0.9 (0.4; 1.3)0.8 (0.3; 1.4)2.73 (2.44; 3.21)
 < 0.001
 < 0.001		2.64 (2.34; 2.88)
 < 0.001
Leptin (pg/ml)2.3 (1.3; 4.2)2.2 (1.5; 3.1)19.0 (15.3; 19.2)
 < 0.001
 = 0.003		19.0 (19.0; 22.6)
 < 0.001
Adiponectin (µg/ml)216 (167; 428)293 (201; 406)195 (156; 262)
 < 0.001		310 (167; 388)
Resistin (ng/ml)26.8 (14.1; 101.9)38.6 (21.3; 114.3)47.2 (28.9; 80.6)42.2 (26.9; 109.6)
Apelin (pg/ml)36 (21; 53)40 (36; 44)22.3 (16.3; 133.2)
 = 0.001		16.3 (16.3; 21.1)
 = 0.011
 = 0.001
Asprosin (ng/ml)0.4 (0; 1.1)0.6 (0; 0.6)0.2 (0; 0.5)0.3 (0; 0.4)
TTH (mU/l)2.1 (1.4; 2.7)2.5 (1.9; 2.7)2.9 (2.2; 4.1)
 < 0.001
 = 0.03		4.2 (4.0; 5.2)
 = 0.001
Т4 (pmol/l)11.9 (10.9; 13.2)11.6 (106; 11.8)12.2 (11.2; 13.1)11.8 (11.4; 12.1)
Prolactin (mU/l)148 (111; 185)181 (135; 228)124 (84.9; 151)
 = 0.035
 = 0.001		133 (75.7; 187)
Insulin (ng/ml)10.2 (8.9; 10.1)
 = 0.007		17.4 (15.7; 22.2)30.1 (18.9; 41.3)
 < 0.001		24.3 (21.5; 34.0)
НОМА-IR1.7 (1.2; 2.4)2.5 (2.0; 3.4)5.6 (3.4; 7.6)
 < 0.001		4.8 (3.8; 5.8)
 = 0.027
FGF21 (ng/ml)11 (10; 18)
 = 0.005		30.5 (18.8; 44.8)18.4 (10.3; 47.6)
 = 0.007		18.4 (9.5; 30)
Irisin (ng/ml)200 (96; 244)244 (96; 244)186.9 (98.2; 293)
 = 0.025		244.1 (92.5; 29)
Adipsin (µg/ml)2.5 (1.7; 3.8)3.5 (2.0; 4.1)4.3 (3.0; 4.0)
 = 0.003		4.3 (2.6; 4.6)
Myostatin (ng/ml)337 (288; 488)488 (438; 488)387.3 (236; 488)361.2 (274; 362)
Oncostatin (pg/ml)10 (7; 16)19 (10.5; 26.5)9 (7; 17)
 = 0.005		12 (7; 17)
Osteocrine (ng/ml)88 (58; 108)82.5 (68.3; 97.3)66.7 (52.1; 96.2)
 = 0.049
 = 0.001		104.3 (92.5; 122)
Biochemical indices
Glucose (mmol/l)3.5 (3.0; 3.9)2.9 (2.9; 3.4)4.4 (3.7; 4.6)
 < 0.001		4.4 (3.9; 4.6)
 = 0.034
ALT (U/l)13.8 (11.1; 18)10.6 (9.7; 15.9)21.3 (13.3; 26.8)
 = 0.007
 = 0.013		29.1 (17.4; 40.2)
 = 0.028
 = 0.026
AST (U/l)24 (21.9; 27.6)19.6 (16.2; 24.2)24.9 (22.3; 28.9)
 = 0.005		34.1 (28.4; 34.8)
 = 0.011
 = 0.021
Total cholesterol (TC) (mmol/l)3.9 (3.5; 4.7)3.8 (3.4; 4.2)3.9 (3.7; 4.2)4.3 (3.8; 4.6)
HDL-cholesterol (mmol/l)1.3 (1.2; 1.5)1.2 (0.9; 1.3)1.2 (1.0; 1.2)
 = 0.002		1.1 (1.0; 1.2)
LDL-cholesterol (mmol/l)2.4 (1.9; 3.0)2.1 (1.4; 2.3)2.1 (1.8; 2.4)2.4 (1.8; 2.8)
VLDL-cholesterol (mmol/l)0.3 (0.2; 0.5)0.5 (0.3; 0.8)0.6 (0.5; 0.7)
 < 0.001		0.7 (0.6; 0.8)
TAG (mmol/l)0.7 (0.5; 1.1)0.9 (0.7; 1.5)1.2 (1; 1.5)
 < 0.001		1.4 (1.2; 1.6)
Atherogenic index of plasma (AIP)1.9 (1.6; 2.5)2.5 (1.9; 3.0)2.4 (1.9; 3.1)
 = 0.016		2.4 (2.1; 2.8)
Comment: The data are presented as median [Q1; Q4]. The table contains statistically significant values ( < 0.05) between the compared groups: —healthy Ser/Ser boys compared to obese Ser/Ser boys; —healthy 447Ter boys compared to obese 447Ter boys; —healthy Ser/Ser boys compared to healthy 447Ter boys; —obese Ser/Ser boys compared to obese 447Ter boys; —obese Ser/Ser boys compared to obese Ser/Ser girls; —obese 447Ter boys compared to obese 447Ter girls.