The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants

Table 2

The levels of adipokines, myokines, hormones, and biochemical indices in the blood of healthy and obese girls with different genotypes for LPL (rs328).

Index	Control group (healthy girls)		Subject group (girls with obesity)
Genotype	Ser447Ser	447Ter	Ser447Ser	447Ter
SDS BMI	0.69 (0.27; 0.9)	0.11 (0.1; 0.5)	2.37 (2.13; 2.61); < 0.001	2.6 (2.14; 2.71); < 0.001
Leptin (pg/ml)	5.0 (3.1; 6.2)	4.5 (3.6; 5.5)	14.6 (12.0; 218.3); < 0.001	14.0 (6.5; 19.1); = 0.034
Adiponectin (µg/ml)	275 (172; 480)	291 (178; 415)	393 (245; 479); = 0.007	186 (142; 214)
Resistin (ng/ml)	97.4 (40.9; 142)	80.1 (41.2; 126.5)	43.9 (27.1; 81.1); = 0.014	43.3 (22.7; 126.8)
Apelin (pg/ml)	31.6 (21.1; 43.9)	118.8 (79.8; 145)	153 (118.8; 225); < 0.001	228 (140.4; 310)
Asprosin (ng/ml)	0.5 (0; 0.9)	0.,6 (0.6; 0.8)	0.2 (0; 0.5); = 0.018	0 (0; 0.1); = 0.006
TTH (mU/l)	2.5 (1.8; 3.4)	1.6 (1.5; 3.2)	3.0 (2.5; 4.2)	3.4 (2.9; 4.8)
Т4 (pmol/l)	11.4 (10.6; 12.5)	10.9 (10.2; 11.5)	11.9 (10.8; 12.3); = 0.004	10.9 (10.9; 11.4)
Prolactin (mU/l)	229 (162; 311)	176 (162.8; 236)	165 (113; 243.5); = 0.011	96.2 (86.1; 117.6); = 0.038
Insulin (ng/ml)	14.6 (13.2; 18.6)	24.7 (15.1; 32.8)	24.7 (19.5; 30.8); < 0.001	26.4 (18.9; 45.7)
НОМА-IR	2.3 (1.9; 3.3)	2.7 (2.1; 3.5)	4.1 (3.3; 6.1); < 0.001	3.6 (3.1; 8.5)
FGF21 (ng/ml)	10 (5.2; 14.5)	5.5 (5.2; 15.5)	18 (6; 24); = 0.008	11 (10.5; 24.5)
Irisin (ng/ml)	96 (52.4; 109.7)	79.5 (63.4; 100.8)	244.1 (195; 360); < 0.001	244 (218.5; 402); = 0.008
Adipsin (µg/ml)	2.4 (1.5; 3.9)	3.4 (2.4; 4.9)	3.1 (2.3; 4.3); = 0.045	3.7 (2.7; 4.0)
Myostatin (ng/ml)	488.3 (336.9; 488.3)	488 (450.2; 488.1)	454 (374; 488)	361 (211; 374)
Oncostatin (pg/ml)	12.9 (9.2; 16.4)	15.8 (13.9; 21.1)	14 (10; 21.5)	15 (13; 38)
Osteocrine (ng/ml)	77.1 (58.9; 96.5)	86.8 (65.5; 131.9)	94 (80; 117.5); = 0.004	103 (80; 128)
Biochemical indices
Glucose (mmol/l)	3.6 (3.2; 3.9); = 0.029	3.1 (2.8; 3.2)	4.2 (3.5; 4.4); = 0.025	3.9 (3.5; 4.1)
ALT (U/l)	13.4 (11.1; 16.3)	11.6 (10.5; 23.1)	15.2 (12.3; 17.8)	13 (11.9; 14.1)
AST (U/l)	20.3 (18.6; 26.2)	22.2 (20; 24.7)	21.4 (19.7; 24.9)	21.2 (18.7; 24.8)
Total cholesterol (TC) (mmol/l)	4.1 (3.7; 4.6); = 0.012	5.0 (4.5; 5.5)	4.0 (3.6; 4.2)	3.9 (3.7; 4.3); = 0.014
HDL-cholesterol (mmol/l)	1.3 (1.1; 1.5)	1.3 (1.1; 1.7)	1.3 (1.0; 1.4); = 0.013	1.1 (0.9; 1.6)
LDL-cholesterol (mmol/l)	2.3 (1.8; 2.6)	2.6 (2.4; 2.9)	2.2 (1.9; 2.4)	2.1 (1.7; 2.4)
VLDL-cholesterol (mmol/l)	0.4 (0.3; 0.6)	0.8 (0.5; 1.2)	0.5 (0.4; 0.8); = 0.009	0.6 (0.4; 0.8)
TAG (mmol/l)	0.8 (0.6; 1.1)	1.6 (1.0; 2.3)	1.1 (0.9; 1.5); = 0.007	1.1 (0.7; 1.6)
Atherogenic index of plasma (AIP)	2.0 (1.6; 2.6)	2.9 (2.4; 3.5)	2.5 (1.9; 2.8)	2.0 (1.8; 3.1)

Comment: The data are presented as median [Q1; Q4]. The table contains statistically significant values ( < 0.05) between the compared groups: —healthy Ser/Ser girls compared to obese Ser/Ser girls; —healthy 447Ter girls compared to obese 447Ter girls; —healthy Ser/Ser girls compared to healthy 447Ter girls; —obese Ser/Ser girls compared to obese 447Ter girls;