The Concentrations of Interleukin-6, Insulin, and Glucagon in the Context of Obesity and Type 2 Diabetes and Single Nucleotide Polymorphisms in IL6 and INS Genes
Table 5
Concentrations of the selected parameters associated with glucose metabolism in terms of rs1800795 (IL6).
Parameter
Control group (N = 50)
Obese group (N = 45)
Diabetic group (N = 23)
G/G (N = 18)
G/C (N = 18)
C/C (N = 14)
G/G (N = 15)
G/C (N = 23)
C/C (N = 7)
G/G (N = 3)
G/C (N = 9)
C/C (N = 11)
Insulin (mU/L)
6.40; 7.90; 9.00
4.20; 6.30; 8.20
4.50; 5.20; 6.90
7.90; 13.60;
9.65; 14.55;
7.40; 10.25; 19.30
4.09; 13.92; 41.70
10.65; 17.39;
8.13; 9.91; 20.45$$
Glucagon (pg/mL)
59.27; 88.35; 125.93
58.41; 86.54; 97.54
39.20; 74.36; 131.80
44.35; 103.36; 112.20
46.22; 67.35; 106.85
—
82.88; 170.00; 299.41
130.80; 173.18; 195.75
140.13; 181.69; 221.05
IL-6 (pg/mL)
8.85; 12.02; 23.68
6.07; 8.90; 76.92
7.46; 9.91; 20.31
6.10; 6.40;
6.22; 6.87; 13.52
7.06; 8.74; 9.90
6.24; 7.17; 7.18
5.84; 6.01; 8.94
5.92; 6.08; 6.29$$,$$$
Glucose (mmol/L)
4.56; 4.72; 4.83
4.44; 4.81; 5.00
4.44; 4.72; 5.06
4.72; 5.17; 5.50
4.92; 5.17; 5.53
5.03; 5.36; 6.25
6.04; 9.20;
6.60; 6.80; ,$
6.30; 8.25; 8.50$$
CRP (mg/L)
0.20; 0.47; 0.80
0.37; 0.89; 1.15
0.32; 0.61; 0.91
1.11; 1.22;
0.97; 1.34;
1.80; 4.52; 6.93$$
0.62; 1.33; 14.24
1.38; 2.79; 5.
0.69; 1.04; 2.25
Cu (μg/L)
960.21; 1012.89; 1257.32
853.30; 988.99; 1055.65
912.33; 994.74; 1059.29
889.84; 1001.59; 1114.89
991.47; 1075.33; 1167.87
974.55; 1148.39; 1321.91
1011.00; 1206.00; 1490.00
1121.00; 1248.00; 1325.
1016.00; 1082.00; 1221.00$$
Zn (μg/L)
940.35 ± 130.09
969.25 ± 126.96
987.86 ± 151.71
943.94 ± 118.78
985.36 ± 92.38
880.19 ± 133.20
802.00 ± 47.29
902.67 ± 77.86
899.36 ± 102.83
Cd (mg/g Hg)
1.07; 2.46; 3.39
1.63; 1.87; 3.56
1.62; 2.43; 3.64
1.54; 2.91; 6.04
1.78; 4.22; 5.50
2.07; 4.49; 11.13
1.69; 3.09; 5,∗∗
2.52; 3.59; 7,$
1.79; 3.83; 5.04$$,$$$
Values are shown as mean value ± standard deviation or {1st quartile; median; 3rd quartile}. Data were obtained with the Kruskal–Wallis test with the post hoc Dunn’s test. In the case of zinc, data were obtained with the ANOVA. N: number of patients; compared to control group with G/G genotype; compared to obese group with G/G genotype; compared to control group with G/C genotype; $ compared to obese group with G/C genotype; $$ compared to control group with C/C genotype; $$$ compared to obese group with C/C genotype. Bold values represent medians.
