The Concentrations of Interleukin-6, Insulin, and Glucagon in the Context of Obesity and Type 2 Diabetes and Single Nucleotide Polymorphisms in IL6 and INS Genes
Table 7
The concentrations of the selected parameters associated with glucose metabolism in terms of rs3842729 (INS).
Parameters
Control group (N = 50)
Obese group (N = 45)
Diabetic group (N = 23)
A/G (N = 23)
G/G (N = 27)
A/G (N = 29)
G/G (N = 16)
A/G (N = 9)
G/G (N = 14)
Insulin (mU/L)
4.90; 7.00; 8.20
4.70; 6.80; 9.40
8.90; 10.95;
11.50; 14.60;
—
—
Glucagon (pg/mL)
60.90; 92.79; 120.72
50.92; 82.02; 119.29
44.35; 67.35; 112.20
47.60; 103.36; 106.85
130.80; 182.98; 2,∗∗
140.13; 165.30; 195.
IL-6 (pg/mL)
7.99; 10;83; 30.59
7.28; 10.56; 38.01
6.28; 6.73; 11.20
6.22; 6.46; 9.51
5.82; 5.96; 6.
5.98; 6.36; 7.
Glucose (mmol/L)
4.56; 4.78; 4.94
4.44; 4.64; 5.06
4.92; 5.17; 5.
4.72; 5.17; 5.61
—
—
CRP (mg/L)
0.37; 0.65; 0.93
0.19; 0.43; 0.94
0.99; 1.33;
1.14; 1.80; 5.
0.69; 1.33; 4.
1.03; 1.72; 3.7
Cu (μg/L)
1018.49 ± 114.23
1007.20 ± 200.71
1084.97 ± 136.46
1072.88 ± 173.16
—
—
Zn (μg/L)
924.60 ± 115.18
997.67 ± 141.60
953.02 ± 89.37
953.64 ± 145.95
—
—
Cd (mg/g Hg)
1.49; 2.25; 3.51
1.46; 2.44; 3.60
1.59; 2.91; 4.92
2.73; 6.04; 14.
—
—
Values are shown as mean value ± standard deviation or {1st quartile; median; 3rd quartile}. Data were obtained with the Kruskal–Wallis test with the post hoc Dunn’s test (glucagon, IL-6, and CRP), with the Mann–Whitney U test (insulin, glucose, and cadmium), and with the Student’s t-test (copper and zinc). N: number of patients; compared to control group with A/G genotype; compared to obese group with A/G genotype; compared to control group with G/G genotype. Bold values represent medians.
