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Developmental Programming: Underlying Mechanisms and Potential Therapies

Call for Papers

Over recent decades there has been a rapid rise in metabolic disorders such as obesity throughout the developed and developing world. Whilst lifestyle and societal habits have contributed to this epidemic, there is now increasing evidence that the early developmental environment of an infant can play a pivotal role in the “programming” of an adverse physiological phenotype in later life. A wide range of exposures during critical periods of development has been shown to influence disease risk including suboptimal maternal nutrition, maternal stress, maternal smoking, and fetal hypoxia. Animal models are providing essential information about the underlying cellular and molecular mechanisms that contribute to the adverse phenotypic outcomes. The use of this information will aid our understanding of the programming signals related to maternal and paternal overnutrition and the improved healthcare for both mother and infant.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the underlying mechanisms of early life programming events, the development of strategies to prevent these conditions, and the evaluation of outcomes. We are particularly interested in articles describing new insights from animal models, the new modalities for clinical characterization that enable early identification of at-risk pregnancies; advances in molecular biology and molecular diagnostics; and current concepts of therapeutic intervention during gestation and measuring outcomes from treatment trials. Potential topics include, but are not limited to:

  • Central and peripheral mechanisms
  • Maternal environment and programming signals
  • Maternal intervention strategies
  • Most recent advances in the role of epigenetic mechanisms including small noncoding RNAs
  • Recent insights into the methodologies of implementing animal models of developmental programming
  • Latest advances in clinical research and intervention strategies
  • Healthcare advances to mother and father that could improve offspring health

Before submission authors should carefully read over the journal’s Author Guidelines, which are located at http://www.hindawi.com/journals/jobe/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/jobe/dpup/ according to the following timetable:

Manuscript DueFriday, 6 June 2014
First Round of ReviewsFriday, 29 August 2014
Publication DateFriday, 24 October 2014

Lead Guest Editor

  • Claire Stocker, Department of Metabolic Disease, University of Buckingham, Buckingham MK18 1EG, UK

Guest Editors

  • Susan Ozanne, Department of Clinical Biochemistry, Institute of Metabolic Science, University of Cambridge, Cambridge, CB2 OQQ, UK
  • Kieron Rooney, Faculty of Health Science, University of Sydney, Sydney, NSW 2141, Australia