Table 6: Recent randomised controlled trials of weight loss therapies with 2-years followup.

Drug No subjects Outcomes Serious adverse events Reference Absolute weight loss (kg) (95% CI) ≥5% weight loss ≥10% weight loss Change in WC (cm) Lorcaserin P-684 50.3% 7.7% NS [120] L-564 67.9% 22.6% Taranabant P-244 1.4 (0.3, 2.5) 30.3% 13.4 −2.7 (1.5, 3.8) NS [23] TB 2 mg-264 6.4 (5.3, 7.4), 59.6, 33, 1 −6.3 (5.2, 7.4) TB 4 mg-260 7.6 (6.5, 8.7), 64.8, 37.9, −7.0 (5.9, 8.1),

Absolute weight loss = weight loss from baseline; WC: waist circumference, NR: not recorded, TB: taranabant, NS: not significant; P: placebo; L: lorcaserin.