Table 2: Effect of high fat diet AVE7688, Enalapril or Candoxatril on change in serum insulin, leptin, cholesterol, triglycerides, free fatty acids, adiponectin, 8-hydroxy deoxyguanosine, TBARS, and ACE activity.

Determination Control High Fat High Fat + AVE7688 High Fat + Enalapril High Fat + Candoxatril (23) (24) (28) (6) (6) Insulin (ng/mL) 1.28 ±.09 0.67 ± 0.0 3.74 ± 1.1 Leptin (pM) 446 ± 81 2052 ± 38 1442 ± 430 2852 ± 26 Cholesterol (mg/dL) 303 ± 31 680 2 347 ± 1 201 ± 2 255 ± 49 Triglycerides (mg/dL) 41.8 ± 4.1 71.5 ± 11.7 72.0 ± 9.1 67.3 ± 5.3 72.2 ± 8.9 Free fatty acids (mmol/L) 0.10 ± 0.01 0.20 ± 0.0 0.21 ± 0.0 0.28 ± 0.0 0.20 ± 0.04 Adiponectin (μg/mL) 7.9 ± 0.6 11.0 ± 0. 9.5 ± 0.5 7.7 ± 0.7 7.8 ± 0.7 8-OH DG (ng/mL) 1.88 ± 0.10 2.58 ± 0.1 1.91 ± 0.1 1.85 ± 0.09 1.88 ± 0.14 TBARS (g/mL) 0.13 ± 0.01 0.50 ± 0.0 0.26 ± 0.0 0.71 ± 0.0 0.55 ± 0.0 ACE activity (mU/mL/min) 94 ± 8 75 ± 6 23 ± 4 ± 111 ± 14

Data are presented as the mean ± SEM. compared to control; compared to high-fat. ND equals not determined. Parentheses indicate the number of experimental animals in each group.