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Journal of Obesity
Volume 2011 (2011), Article ID 928165, 13 pages
doi:10.1155/2011/928165
Review Article
Pharmacological Treatment of Obesity in Children and Adolescents: Present and Future
Obesity Research Center, Department of Pediatrics, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
Received 27 July 2010; Revised 12 October 2010; Accepted 13 October 2010
Academic Editor: A. Halpern
Copyright © 2011 Lorenzo Iughetti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Linked References
- T. Lobstein, L. Baur, and R. Uauy, “Obesity in children and young people: a crisis in public health,” Obesity Reviews, vol. 5, no. 1, pp. 4–104, 2004. View at Scopus
- Y. Wang and T. Lobstein, “Worldwide trends in childhood overweight and obesity,” International Journal of Pediatric Obesity, vol. 1, no. 1, pp. 11–25, 2006. View at Publisher · View at Google Scholar · View at Scopus
- V. Shrewsbury and J. Wardle, “Socioeconomic status and adiposity in childhood: a systematic review of cross-sectional studies 1990–2005,” Obesity, vol. 16, no. 2, pp. 275–284, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. Cooke and S. Bloom, “The obesity pipeline: current strategies in the development of anti-obesity drugs,” Nature Reviews Drug Discovery, vol. 5, no. 11, pp. 919–931, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Arora and Anubhuti, “Role of neuropeptides in appetite regulation and obesity—a review,” Neuropeptides, vol. 40, no. 6, pp. 375–401, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. P. H. Wilding, “Neuropeptides and appetite control,” Diabetic Medicine, vol. 19, no. 8, pp. 619–627, 2002. View at Publisher · View at Google Scholar · View at Scopus
- G. P. August, S. Caprio, I. Fennoy et al., “Prevention and treatment of pediatric obesity: an endocrine society clinical practice guideline based on expert opinion,” Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 12, pp. 4576–4599, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J.-P. Chanoine, S. Hampl, C. Jensen, M. Boldrin, and J. Hauptman, “Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial,” Journal of the American Medical Association, vol. 293, no. 23, pp. 2873–2883, 2005. View at Publisher · View at Google Scholar · View at PubMed
- S. Srinivasan, G. R. Ambler, L. A. Baur et al., “Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 6, pp. 2074–2080, 2006. View at Publisher · View at Google Scholar · View at PubMed
- J. P. Kay, R. Alemzadeh, G. Langley, L. D'Angelo, P. Smith, and S. Holshouser, “Beneficial effects of metformin in normoglycemic morbidly obese adolescents,” Metabolism, vol. 50, no. 12, pp. 1457–1461, 2001. View at Publisher · View at Google Scholar · View at PubMed
- M. Freemark and D. Bursey, “The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes,” Pediatrics, vol. 107, no. 4, p. E55, 2001.
- K. L. Jones, S. Arslanian, V. A. Peterokova, J.-S. Park, and M. J. Tomlinson, “Effect of metformin in pediatric patients with type 2 diabetes: a randomized controlled trial,” Diabetes Care, vol. 25, no. 1, pp. 89–94, 2002. View at Publisher · View at Google Scholar
- R. I. Berkowitz, T. A. Wadden, A. M. Tershakovec, and J. L. Cronquist, “Behavior therapy and sibutramine for the treatment of adolescent obesity: a randomized controlled trial,” Journal of the American Medical Association, vol. 289, no. 14, pp. 1805–1812, 2003. View at Publisher · View at Google Scholar · View at PubMed
- R. I. Berkowitz, K. Fujioka, S. R. Daniels et al., “Effects of sibutramine treatment in obese adolescents: a randomized trial,” Annals of Internal Medicine, vol. 145, no. 2, pp. 81–90, 2006.
- L. M. García-Morales, A. Berber, C. C. Macias-Lara, C. Lucio-Ortiz, B. E. Del-Rio-Navarro, and L. M. Dorantes-Alvárez, “Use of sibutramine in obese mexican adolescents: a 6-month, randomized, double-blind, placebo-controlled, parallel-group trial,” Clinical Therapeutics, vol. 28, no. 5, pp. 770–782, 2006. View at Publisher · View at Google Scholar · View at PubMed
- A. Godoy-Matos, L. Carraro, A. Vieira et al., “Treatment of obese adolescents with sibutramine: a randomized, double-blind, controlled study,” Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 3, pp. 1460–1465, 2005. View at Publisher · View at Google Scholar · View at PubMed
- E. G. A. H. Van Mil, K. R. Westerterp, A. D. M. Kester, H. A. Delemarre-van De Waal, W. J. M. Gerver, and W. H. M. Saris, “The effect of sibutramine on energy expenditure and body composition in obese adolescents,” Journal of Clinical Endocrinology and Metabolism, vol. 92, no. 4, pp. 1409–1414, 2007. View at Publisher · View at Google Scholar · View at PubMed
- S. R. Daniels, B. Long, S. Crow et al., “Cardiovascular effects of sibutramine in the treatment of obese adolescents: results of a randomized, double-blind, placebo-controlled study,” Pediatrics, vol. 120, no. 1, pp. e147–e157, 2007. View at Publisher · View at Google Scholar · View at PubMed
- J. B. Hauptman, F. S. Jeunet, and D. Hartmann, “Initial studies in humans with the novel gastrointestinal lipase inhibitor Ro 18-0647 (tetrahydrolipstatin),” American Journal of Clinical Nutrition, vol. 55, no. 1, pp. 309S–313S, 1992.
- R. S. Padwal and S. R. Majumdar, “Drug treatments for obesity: orlistat, sibutramine, and rimonabant,” The Lancet, vol. 369, no. 9555, pp. 71–77, 2007. View at Publisher · View at Google Scholar · View at PubMed
- Z. Li, M. Maglione, W. Tu et al., “Meta-analysis: pharmacologic treatment of obesity,” Annals of Internal Medicine, vol. 142, no. 7, pp. 532–546, 2005.
- J. Zhi, R. Moore, L. Kanitra, and T. E. Mulligan, “Effects of orlistat, a lipase inhibitor, on the pharmacokinetics of three highly lipophilic drugs (amiodarone, fluoxetine, and simvastatin) in healthy volunteers,” Journal of Clinical Pharmacology, vol. 43, no. 4, pp. 428–435, 2003. View at Publisher · View at Google Scholar
- J. Zhi, R. Moore, L. Kanitra, and T. E. Mulligan, “Pharmacokinetic evaluation of the possible interaction between selected concomitant medications and orlistat at steady state in healthy subjects,” Journal of Clinical Pharmacology, vol. 42, no. 9, pp. 1011–1019, 2002.
- R. S. MacWalter, H. W. Fraser, K. M. Armstrong, G. Rivera-Miranda, and P. Dion, “Orlistat enhances warfarin effect,” Annals of Pharmacotherapy, vol. 37, no. 4, pp. 510–512, 2003.
- A. Saenz, I. Fernandez-Esteban, A. Mataix, M. Ausejo, M. Roque, and D. Moher, “Metformin monotherapy for type 2 diabetes mellitus,” Cochrane Database of Systematic Reviews, no. 3, Article ID CD002966, 2005.
- R. A. Jackson, M. I. Hawa, J. B. Jaspan et al., “Mechanism of metformin action in non-insulin-dependent diabetes,” Diabetes, vol. 36, no. 5, pp. 632–640, 1987.
- S. Srinivasan, G. R. Ambler, L. A. Baur et al., “Randomized, controlled trial of metformin for obesity and insulin resistance in children and adolescents: improvement in body composition and fasting insulin,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 6, pp. 2074–2080, 2006. View at Publisher · View at Google Scholar · View at PubMed
- M. Stumvoll, N. Nurjhan, G. Perriello, G. Dailey, and J. E. Gerich, “Metabolic effects of metformin in non-insulin-dependent diabetes mellitus,” The New England Journal of Medicine, vol. 333, no. 9, pp. 550–554, 1995. View at Publisher · View at Google Scholar · View at PubMed
- K. Cusi, A. Consoli, and R. A. Defronzo, “Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus,” Journal of Clinical Endocrinology and Metabolism, vol. 81, no. 11, pp. 4059–4067, 1996. View at Publisher · View at Google Scholar
- W. C. Knowler, E. Barrett-Connor, S. E. Fowler et al., “Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin,” The New England Journal of Medicine, vol. 346, no. 6, pp. 393–403, 2002. View at Publisher · View at Google Scholar · View at PubMed
- A. Lutjens and J. L. J. Smit, “Effect of biguanide treatment in obese children,” Helvetica Paediatrica Acta, vol. 31, no. 6, pp. 473–480, 1976.
- W. McNeely and K. L. Goa, “Sibutramine. A review of its contribution to the management of obesity,” Drugs, vol. 56, no. 6, pp. 1093–1124, 1998. View at Publisher · View at Google Scholar
- M. E. Lean, “How does sibutramine work?” International Journal of Obesity, vol. 25, 4, pp. S8–S11, 2001.
- S. E. Barlow, “Expert committee recommendations regarding the prevention, assessment, and treatment of child and adolescent overweight and obesity: summary report,” Pediatrics, vol. 120, pp. S164–192, 2007. View at Publisher · View at Google Scholar · View at PubMed
- W. F. Coutinho, “The obese older female patient: CV risk and the SCOUT study,” International Journal of Obesity, vol. 31, no. 2, pp. S26–S30, 2007. View at Publisher · View at Google Scholar · View at PubMed
- J. Korner and L. J. Aronne, “Pharmacological approaches to weight reduction: therapeutic targets,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2616–2621, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. Lorber, “Obesity in childhood. A controlled trial of anorectic drugs,” Archives of Disease in Childhood, vol. 41, no. 217, pp. 309–312, 1966. View at Scopus
- M. C. Mancini and A. Halpern, “Pharmacological treatment of obesity,” Arquivos Brasileiros de Endocrinologia e Metabologia, vol. 50, no. 2, pp. 377–389, 2006. View at Publisher · View at Google Scholar · View at Scopus
- J. K. Warnock, A. H. Clayton, H. A. Shaw, and T. O'Donnell, “Onset of menses in two adult patients with Prader-Willi syndrome treated with fluoxetine,” Psychopharmacology Bulletin, vol. 31, no. 2, pp. 239–242, 1995. View at Scopus
- J. C. G. Halford, J. A. Harrold, E. J. Boyland, C. L. Lawton, and J. E. Blundell, “Serotonergic drugs: effects on appetite expression and use for the treatment of obesity,” Drugs, vol. 67, no. 1, pp. 27–55, 2007. View at Publisher · View at Google Scholar · View at Scopus
- S. W. J. Lamberts, A.-J. van der Lely, W. W. de Herder, and L. J. Hofland, “Drug therapy: octreotide,” The New England Journal of Medicine, vol. 334, no. 4, pp. 255–260, 1996. View at Scopus
- A. J. Krentz, P. J. Boyle, L. M. Macdonald, and D. S. Schade, “Octreotide: a long-acting inhibitor of endogenous hormone secretion for human metabolic investigations,” Metabolism, vol. 43, no. 1, pp. 24–31, 1994. View at Publisher · View at Google Scholar · View at Scopus
- A. M. Haqq, D. D. Stadler, R. G. Rosenfeld et al., “Circulating ghrelin levels are suppressed by meals and octreotide therapy in children with Prader-Willi syndrome,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 8, pp. 3573–3576, 2003. View at Publisher · View at Google Scholar · View at Scopus
- H. J. Grill and G. P. Smith, “Cholecystokinin decreases sucrose intake in chronic decerebrate rats,” American Journal of Physiology, vol. 254, no. 6, pp. 853–856, 1988. View at Scopus
- R. H. Lustig, F. Greenway, P. Velasquez-Mieyer et al., “A multicenter, randomized, double-blind, placebo-controlled, dose-finding trial of a long-acting formulation of octreotide in promoting weight loss in obese adults with insulin hypersecretion,” International Journal of Obesity, vol. 30, no. 2, pp. 331–341, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. H. Lustig, P. S. Hinds, K. Ringwald-Smith et al., “Octreotide therapy of pediatric hypothalamic obesity: a double-blind, placebo-controlled trial,” Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 6, pp. 2586–2592, 2003. View at Scopus
- P. A. Velasquez-Mieyer, P. A. Cowan, K. L. Arheart et al., “Suppression of insulin secretion is associated with weight loss and altered macronutrient intake and preference in a subset of obese adults,” International Journal of Obesity, vol. 27, no. 2, pp. 219–226, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Ezzat, P. J. Snyder, W. F. Young et al., “Octreotide treatment of acromegaly: a randomized, multicenter study,” Annals of Internal Medicine, vol. 117, no. 9, pp. 711–718, 1992. View at Scopus
- Y.-L. Liu, S. Toubro, A. Astrup, and M. J. Stock, “Contribution of β3-adrenoceptor activation to ephedrine induced thermogenesis in humans,” International Journal of Obesity, vol. 19, no. 9, pp. 678–685, 1995. View at Scopus
- A. Astrup, C. Lundsgaard, J. Madsen, and N. J. Christensen, “Enhanced thermogenic responsiveness during chronic ephedrine treatment in man,” American Journal of Clinical Nutrition, vol. 42, no. 1, pp. 83–94, 1985. View at Scopus
- F. Greenway, L. de Jonge, E. Tucker, J. Rood, and S. Smith, “Caffeine and ephedrine become more beta-3 selective with time,” Obesity Research, vol. 8, supplement 1, pp. 70–82, 2000.
- R. De Matteis, J. R. S. Arch, M. L. Petroni, D. Ferrari, S. Cinti, and M. J. Stock, “Immunohistochemical identification of the β3-adrenoceptor in intact human adipocytes and ventricular myocardium: effect of obesity and treatment with ephedrine and caffeine,” International Journal of Obesity, vol. 26, no. 11, pp. 1442–1450, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. Molnár, K. Török, E. Erhardt, and S. Jeges, “Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents,” International Journal of Obesity, vol. 24, no. 12, pp. 1573–1578, 2000. View at Scopus
- M. Hallschmid, R. Smolnik, G. McGregor, J. Born, and H. L. Fehm, “Overweight humans are resistant to the weight-reducing effects of melanocortin4-10,” Journal of Clinical Endocrinology and Metabolism, vol. 91, no. 2, pp. 522–525, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- N. J. Underdown, C. R. Hiley, and W. R. Ford, “Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism,” British Journal of Pharmacology, vol. 146, no. 6, pp. 809–816, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K.-V. Chin, “Small molecule intervention for obesity,” WO08048636, 2008.
- A. Uslu, “Pharmaceutical formulations comprising lipase inhibitor,” WO2008082373, 2008.
- E. Ravussin, S. R. Smith, J. A. Mitchell et al., “Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy,” Obesity, vol. 17, no. 9, pp. 1736–1743, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- C. Weyer, P. A. Tataranni, S. Snitker, E. Danforth Jr., and E. Ravussin, “Increase in insulin action and fat oxidation after treatment with CL 316,243, a highly selective β3-adrenoceptor agonist in humans,” Diabetes, vol. 47, no. 10, pp. 1555–1561, 1998. View at Publisher · View at Google Scholar · View at Scopus
- J. R. S. Arch, “The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from β3-adrenoceptor agonists,” Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 378, no. 2, pp. 225–240, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. P. Bradley, R. Kulstad, and D. A. Schoeller, “Exenatide and weight loss,” Nutrition, vol. 26, no. 3, pp. 243–249, 2010. View at Publisher · View at Google Scholar · View at PubMed
- K. Niswender, “Diabetes and obesity: therapeutic targeting and risk reduction—a complex interplay,” Diabetes, Obesity and Metabolism, vol. 12, no. 4, pp. 267–287, 2010. View at Publisher · View at Google Scholar · View at PubMed
- W. R. Ewing, C. Mapelli, R. B. Sulsky, et al., “Human glucagon-like-peptide-1 modulators and their use in treatment of diabetes and related conditions,” US20080242593, 2008.
- L. Hansen and H. B. Mortensen, “Use of GLP1-Agonists in the treatment of patients with type I diabetes,” WO2005023291, 2005.
- J. Korner and L. J. Aronne, “Pharmacological approaches to weight reduction: therapeutic targets,” Journal of Clinical Endocrinology and Metabolism, vol. 89, no. 6, pp. 2616–2621, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- Z. Li, M. Maglione, W. Tu et al., “Meta-analysis: pharmacologic treatment of obesity,” Annals of Internal Medicine, vol. 142, no. 7, pp. 532–546, 2005. View at Scopus
- N. T. Bello and M. R. Zahner, “Tesofensine, a monoamine reuptake inhibitor for the treatment of obesity,” Current Opinion in Investigational Drugs, vol. 10, no. 10, pp. 1105–1116, 2009. View at Scopus
- R. Padwal, “Contrave, a bupropion and naltrexone combination therapy for the potential treatment of obesity,” Current Opinion in Investigational Drugs, vol. 10, no. 10, pp. 1117–1125, 2009. View at Scopus
- F. L. Greenway, K. Fujioka, R. A. Plodkowski et al., “Effect of naltrexone plus bupropion on weight loss in overweight and obese adults (COR-I): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial,” The Lancet, vol. 376, no. 9741, pp. 595–605, 2010. View at Publisher · View at Google Scholar
- H. Bays, “Phentermine, topiramate and their combination for the treatment of adiposopathy ('sick fat') and metabolic disease,” Expert Review of Cardiovascular Therapy, vol. 8, no. 12, pp. 1777–1801, 2010.
- M. Rinaldi-Carmona, F. Barth, M. Héaulme et al., “Biochemical and pharmacological characterisation of SR141716A, the first potent and selective brain cannabinoid receptor antagonist,” Life Sciences, vol. 56, no. 23-24, pp. 1941–1947, 1995. View at Publisher · View at Google Scholar · View at Scopus
- M. A. M. Carai, G. Colombo, and G. L. Gessa, “Rimonabant: the first therapeutically relevant cannabinoid antagonist,” Life Sciences, vol. 77, no. 19, pp. 2339–2350, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- Y. L. Liu, I. P. Connoley, C. A. Wilson, and M. J. Stock, “Effects of the cannabinoid CB1 receptor antagonist SR141716 on oxygen consumption and soleus muscle glucose uptake in Lepob/Lep ob mice,” International Journal of Obesity, vol. 29, no. 2, pp. 183–187, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- D. Osei-Hyiaman, M. DePetrillo, P. Pacher et al., “Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity,” Journal of Clinical Investigation, vol. 115, no. 5, pp. 1298–1305, 2005. View at Publisher · View at Google Scholar · View at Scopus
- D. Cota, G. Marsicano, M. Tschöp et al., “The endogenous cennabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis,” Journal of Clinical Investigation, vol. 112, no. 3, pp. 423–431, 2003. View at Publisher · View at Google Scholar · View at Scopus
- J.-P. Després, A. Golay, and L. Sjöström, “Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia,” The New England Journal of Medicine, vol. 353, no. 20, pp. 2121–2134, 2005. View at Publisher · View at Google Scholar · View at PubMed
- V. Di Marzo and I. Matias, “Endocannabinoid control of food intake and energy balance,” Nature Neuroscience, vol. 8, no. 5, pp. 585–589, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. Gómez, M. Navarro, B. Ferrer et al., “A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding,” Journal of Neuroscience, vol. 22, no. 21, pp. 9612–9617, 2002. View at Scopus
- M. Gary-Bobo, G. Elachouri, B. Scatton, G. Le Fur, F. Oury-Donat, and M. Bensaid, “The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes,” Molecular Pharmacology, vol. 69, no. 2, pp. 471–478, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. R. Helvaci, H. Kaya, A. Borazan, C. Ozer, M. Seyhanli, and A. Yalcin, “Metformin and parameters of physical health,” Internal Medicine, vol. 47, no. 8, pp. 697–703, 2008. View at Publisher · View at Google Scholar · View at Scopus
- C. Addy, P. Rothenberg, S. Li et al., “Multiple-dose pharmacokinetics, pharmacodynamics, and safety of taranabant, a novel selective cannabinoid-1 receptor inverse agonist, in healthy male volunteers,” Journal of Clinical Pharmacology, vol. 48, no. 6, pp. 734–744, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- R. Adler, K. B. Landa, M. Manthorpe, and S. Varon, “Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neurons,” Science, vol. 204, no. 4400, pp. 1434–1436, 1979. View at Scopus
- L.-F. H. Lin, D. Mismer, J. D. Lile et al., “Purification, cloning, and expression of ciliary neurotrophic factor (CNTF),” Science, vol. 246, no. 4933, pp. 1023–1025, 1989. View at Scopus
- S. Davis, T. H. Aldrich, D. M. Valenzuela et al., “The receptor for ciliary neurotrophic factor,” Science, vol. 253, no. 5015, pp. 59–63, 1991. View at Scopus
- N. Y. Ip, S. H. Nye, T. G. Boulton et al., “CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130,” Cell, vol. 69, no. 7, pp. 1121–1132, 1992. View at Publisher · View at Google Scholar · View at Scopus
- M. Sendtner, Y. Arakawa, K. A. Stockli, G. W. Kreutzberg, and H. Thoenen, “Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival,” Journal of Cell Science, vol. 100, no. 15, pp. 103–109, 1991. View at Scopus
- R. G. Miller, J. H. Petajan, W. W. Bryan et al., “A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis,” Annals of Neurology, vol. 39, no. 2, pp. 256–260, 1996. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- W. Pan, A. J. Kastin, L. M. Maness, and J. M. Brennan, “Saturable entry of ciliary neurotrophic factor into brain,” Neuroscience Letters, vol. 263, no. 1, pp. 69–71, 1999. View at Publisher · View at Google Scholar · View at Scopus
- B. Xu, M. G. Dube, P. S. Kalra et al., “Anorectic effects of the cytokine, ciliary neurotropic factor, are mediated by hypothalamic neuropeptide Y: comparison with leptin,” Endocrinology, vol. 139, no. 2, pp. 466–473, 1998. View at Publisher · View at Google Scholar · View at Scopus
- P. D. Lambert, K. D. Anderson, M. W. Sleeman et al., “Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity,” Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 8, pp. 4652–4657, 2001. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- S. Zvonic, P. Cornelius, W. C. Stewart, R. L. Mynatt, and J. M. Stephens, “The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes,” Journal of Biological Chemistry, vol. 278, no. 4, pp. 2228–2235, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- M. Scott, “Methods for identifyng a candidate for treatment of obesity,” WO2006017156, 2006.
- B.-A. Bengtsson, S. Eden, L. Lonn et al., “Treatment of adults with growth hormone (GH) deficiency with recombinant human GH,” Journal of Clinical Endocrinology and Metabolism, vol. 76, no. 2, pp. 309–317, 1993. View at Publisher · View at Google Scholar · View at Scopus
- F. M. Ng, J. Sun, L. Sharma, R. Libinaka, W. J. Jiang, and R. Gianello, “Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone,” Hormone Research, vol. 53, no. 6, pp. 274–278, 2000. View at Publisher · View at Google Scholar · View at Scopus
- J. E. Wikberg and F. Mutulis, “Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction,” Nature reviews. Drug discovery, vol. 7, no. 4, pp. 307–323, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- L. E. Diamond, D. C. Earle, R. C. Rosen, M. S. Willett, and P. B. Molinoff, “Double-blind, placebo-controlled evaluation of the safety, pharmacokinetic properties and pharmacodynamic effects of intranasal PT-141, a melanocortin receptor agonist, in healthy males and patients with mild-to-moderate erectile dysfunction,” International Journal of Impotence Research, vol. 16, no. 1, pp. 51–59, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- J. P. Beck and B. D. Wakefield, “Novel mch receptor antagonists,” CN101072775, 2007.
- R. A. Houghten, C. Dooley, A. Nefzi, Z. Wang, O. Civelli, and H. Nagasaki, “Melanin-concentrating hormone receptor antagonists and methods of use,” US 20080255218, 2008.
- D. R. Luthin, “Anti-obesity effects of small molecule melanin-concentrating hormone receptor1 (MCHR1) antagonists,” Life Sciences, vol. 81, no. 6, pp. 423–440, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
- K. A. Anderson, T. J. Ribar, F. Lin et al., “Hypothalamic CaMKK2 contributes to the regulation of energy balance,” Cell Metabolism, vol. 7, no. 5, pp. 377–388, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus