|
| PTP1B-deficient mouse model | Body weight/adiposity phenotype | Leptin sensitivity | Glucose homeostasis | References |
|
Global
(whole body) | Decreased | Increased | Improved GTT
Improved ITT | [3, 4] |
Brain specific
(Nestin-Cre) | Decreased | Increased | Improved GTT
Improved ITT | [45] |
POMC-neuron specific
(POMC-Cre) | Decreased | Increased | Improved GTT
Improved ITT | [46] |
Adipose/macrophage specific
(aP2-Cre) | Increased | ND | ND | [45] |
Muscle specific
(MCK-Cre) | No change | ND | Improved GTT
Improved ITT | [48] |
Liver specific
(Albumin-Cre) | No change | ND | Improved GTT | [49] |
Adipocyte specific
(adiponectin-Cre) | No change in body weight
Increased adipocyte size | Decreased | Mild glucose intolerance | [50] |
LepRb specific
(LepRb-Cre) | Decreased | Increased | Improved GTT | Unpublished (Tsou and Bence) |
|