Journal of Oral Oncology http://www.hindawi.com The latest articles from Hindawi Publishing Corporation © 2014 , Hindawi Publishing Corporation . All rights reserved. Comparative Study of Superselective Intra-Arterial Chemoradiotherapy versus Radical Surgery on Distant Metastasis for Advanced Oral Cancer Mon, 14 Apr 2014 12:53:13 +0000 http://www.hindawi.com/journals/joo/2014/192734/ Background. Distant metastasis is considerably more frequent in superselective intra-arterial chemoradiotherapy than other radical treatments for advanced oral cancers. However, there is no evidence supporting such claim. The purpose of this study was to report our experience in superselective intra-arterial chemoradiotherapy and conventional surgical management with particular focus on distant metastasis. Methods. One hundred seventy-two patients with oral squamous cell carcinoma in stages III and IV were included in this study. Retrospective analysis for DM rates and background between surgical management and superselective intra-arterial chemoradiotherapy was performed. Results. Distant metastasis developed clinically was detected in 24 out of 141 patients (17.0%) treated surgically and in 6 out of 31 patients (19.4%) treated with superselective intra-arterial chemoradiotherapy. There was no significant difference in the rate of distant metastasis between the 2 groups. Comparison of patients in both groups with and without distant metastasis revealed no differences in age, T classification, N classification, and treatment effect. Neck recurrence was the only significant risk factor for distant metastasis. Conclusion. No significant difference was found in the rate of distant metastasis between patients treated with surgical treatment and superselective intra-arterial chemoradiotherapy, and additional effort is needed to reduce the risk of distant metastasis. Wataru Kobayashi, Beng Gwan Teh, Norihiko Narita, Ryohei Ito, Yuki Saito, Ken Furudate, Hiroto Kimura, Sinya Kakehata, and Hideo Kawaguchi Copyright © 2014 Wataru Kobayashi et al. All rights reserved. Head and Neck Solitary Extramedullary Plasmacytoma Tue, 04 Feb 2014 00:00:00 +0000 http://www.hindawi.com/journals/joo/2014/238698/ Introduction. This study aimed to report the characteristics and treatment outcome of 13 patients with solitary extramedullary plasmacytomas of the head and neck and analytical literature review. Materials and Methods. Nine patients (69%) were treated with gross surgical resection followed by radiotherapy, three (23%) were primarily treated with radiotherapy alone, and one (8%) was treated with surgery alone. Results. There were 3 women and 10 men with the median age of 52 years. Nasal cavity (46%) and paranasal sinuses (23%) were the most common primary sites. After a median follow-up of 28 months, 10 patients are alive and free of disease, one is alive with multiple myeloma, and two died of multiple myeloma. In the literature review the median age was 58 years and male/female ratio was 2.7. Sinonasal tract was the most common primary site. Ten-year local control and progression to multiple myeloma rates were 88% and 23%, respectively. The 5- and the 10-year overall survival rates were 71 and 69%, respectively. Conclusion. Radiation therapy with or without surgery is an effective treatment for patients with head and neck extramedullary plasmacytoma. However, long-term follow-up for detection of local recurrence and progression to multiple myeloma is essential. Bijan Khademi, Zohreh Zandifar, Mohammad Mohammadianpanah, Sayed Hasan Hamedi, Samira Razzaghi, Sareh Mahdavi, and Leila Moaddabshoar Copyright © 2014 Bijan Khademi et al. All rights reserved. Awareness of Oral Cancer in a Northwestern Nigerian State: Assessing the Knowledge, Opinion, and Practice of Traditional Healers and Herbalists Wed, 18 Dec 2013 15:52:23 +0000 http://www.hindawi.com/journals/joo/2013/263150/ Background: Traditional healers/herbalists remain one of the most accessible and popular options of care to people suffering from cancers particularly at the community level in Nigeria. The majority of patients with oral cancer present at the terminal stage after exploring unorthodox care. This study assesses the awareness of oral cancer among traditional caregivers in Kano State, Northwestern (NW) Nigeria. Methods: Self-administered, structured questionnaires were administered to a cross section of 21 traditional caregivers. Results: Of the 21 traditional caregivers studied, the majority (66.7%) had never heard of oral cancer and only 7 (33.3%) were aware. The level of knowledge on oral cancer was assessed using a scoring system classifying respondents as having adequate (>50%) or inadequate (<50%) knowledge. There was a significant educational status gap as respondents with informal education had lesser knowledge than that of their counterparts who had formal education (61.9% versus 19.0%) (P = 0.012). Conclusions: It is important to have allied healthcare providers informed about oral cancer, as their knowledge and awareness of oral cancer and its risk factors, which were low in our study, are vital in prevention and early detection. Impact: This study provides an insight into oral cancer prevention using traditional herbalists who are popular caregivers for those seeking health-related solutions. Rafael A. Adebola, Babatunde O. Bamgbose, Joshua B. Adeoye, and Taiwo G. Amole Copyright © 2013 Rafael A. Adebola et al. All rights reserved. The Outline of Prognosis and New Advances in Diagnosis of Oral Squamous Cell Carcinoma (OSCC): Review of the Literature Wed, 28 Aug 2013 15:58:26 +0000 http://www.hindawi.com/journals/joo/2013/519312/ Objective. Oral squamous cell carcinoma (OSCC) has a remarkable incidence over the world and a fairly strenuous prognosis, encouraging further research on the prognostic factors and new techniques for diagnosis that might modify disease outcome. Data Sources. A web-based search for all types of articles published was initiated using Medline/Pub Med, with the key words such as oral cancer, prognostic factors of oral cancer, diagnostic method of oral cancer, and imaging techniques for diagnosis of oral cancer. The search was restricted to articles published in English, with no publication date restriction (last update April, 2013). Review Methods. In this paper, I approach the factors of prognosis of OSCC and the new advances in diagnostic technologies as well. I also reviewed available studies of the tissue fluorescence spectroscopy and other noninvasive diagnostic aids for OSCC. Results. The outcome is greatly influenced by the stage of the disease (especially TNM). Prognosis also depends or varies with tumour primary site, nodal involvement, tumour thickness, and the status of the surgical margins. Conclusion. Tumour diameter is not the most accurate when compared to tumour thickness or depth of invasion, which can be related directly to prognosis. There is a wide agreement on using ultrasound guided fine needle aspiration biopsies in the evaluation of lymph node metastasis. Esam Ahmad Omar Copyright © 2013 Esam Ahmad Omar. All rights reserved. Assessment of Quality of Life and Speech after Implant-Retained Oral Rehabilitation in Head and Neck Cancer Patients Mon, 17 Jun 2013 14:40:06 +0000 http://www.hindawi.com/journals/joo/2013/283290/ Aim. To assess quality of life and speech after rehabilitation with implant-retained dental prosthesis in head and neck cancer patients. Material and Methods. Twenty-six patients who were diagnosed with tumour of the maxilla and mandible were selected for rehabilitation with implant-retained dental prosthesis following resection and reconstructive surgery. They were evaluated for quality of life (EORTC QLQ-C30 and H-N35 questionnaires, version 3), speech, and swallowing (questionnaire and Dr. Speech software, version 4) before implant treatment and at six-, twelve-, and eighteen-month followup. Statistical analysis of quality of life, speech, and swallowing for different duration of their preoperative status was done. Quality of life, speech, and swallowing in grafted and native groups and radiated and nonradiated groups were also compared. Results. Quality of life was statistically significant in scale of pain, speech, and trouble with social eating, pain killers, and weight loss. It was insignificant when radiated and nonradiated or grafted and native jaw groups were compared. Improvement in movement of the tongue, swallowing ability, salivation taste, and intelligibility of speech was also observed. Conclusion. The surgical treatment of head and neck cancers with microvascular surgery and dental rehabilitation with implants restores function, esthetics, and patient’s well-being. Kanchan P. Dholam, Hrishikesh A. Pusalkar, Gurmeet Kaur Bachher, and Priyanka Piyush Somani Copyright © 2013 Kanchan P. Dholam et al. All rights reserved.