Table 2: Top 10 single-marker associations with severe diabetic retinopathy among Mexican-Americans from Starr County, Texas.

dbSNP rs# Chr ${\text{Position}}^{*}$ Minor/major allele MAF in Cases MAF in Controls $P$-${\text{value}}^{\S }$ ${\text{OR}}^{+}$ (95%CI) Nearest ${\text{gene}}^{*}$ Distance/ relationship to gene rs2300782 5 110816684 A/G 0.512 0.322 $6.04E-05$ 2.64 (1.64–4.25) CAMK4 intron/0 rs10519765 15 30992716 A/G 0.136 0.294 $6.21E-05$ 0.30 (0.16–0.54) FMN1 intron/0 rs899036 11 41639486 C/A 0.125 0.210 $2.52E-04$ 0.32 (0.17–0.59) API5 upstream/ 1650623 rs10501943 11 99452209 C/T 0.195 0.086 $2.53E-04$ 3.04 (1.68–5.52) CNTN5 intron/0 rs1445754 5 83611387 A/T 0.143 0.273 $3.35E-04$ 0.37 (0.22–0.64) EDIL3 intron/0 rs1197310 3 134610914 T/A 0.540 0.435 $3.35E-04$ 2.25 (1.45–3.51) BFSP2 intron/0 rs699549 2 4683138 T/C 0.115 0.043 $3.49E-04$ 4.27 (1.93–9.47) — — rs763970 2 138352603 A/C 0.330 0.206 $4.00E-04$ 2.25 (1.44–3.52) HNMT upstream/ 85675 rs599019 18 284495 G/T 0.030 0.131 $4.06E-04$ 0.15 (0.05–0.43) COLEC12 downstream/ 24861 rs6427247 1 168647104 G/A 0.360 0.221 $4.56E-04$ 2.17 (1.41–3.35) SCYL1BP1 upstream/ 120790

${}^{*}$Affymetrix NetAffx annotation build 25, NCBI genome build 36.1. ${}^{\S }P$-value of logistic regression under additive genetic model, adjusted for age, gender, diabetes duration, and HbA1c level. ${}^{+}$odds ratios of the minor allele.