The Role of FRMD7 in Idiopathic Infantile Nystagmus

Figure 1

A schematic representation of the structure of the FRMD7 protein. It contains an N-terminal FERM domain (green) and FERM-adjacent (FA) domain (yellow). The FA domain consists of the 3 lobes F1 (lobe A), F2 (lobe B) and F3 (lobe C). The positions of IIN mutations within FRMD7 have been indicated. Many of the mutations cluster around the F3 lobe of the FERM domain and the FA domain.