Involvement of TAGE-RAGE System in the Pathogenesis of Diabetic Retinopathy

Figure 2

Production routes of glyceraldehyde-derived AGEs (Glycer-AGEs) in vivo. TAGE; toxic AGEs (glyceraldehyde-derived AGEs), RAGE; receptor for AGEs, ROS; reactive oxygen species, HFCS; high-fructose corn syrup, AR; aldose reductase, SDH; sorbitol dehydrogenase, FK; fructokinase, GAPDH; glyceraldehyde-3-phosphate dehydrogenase, *; TAGE.