Human Genetics of Diabetic Retinopathy: Current Perspectives

Table 2

Potential chromosomal regions linked to DR (LOD scores $>$1).

Chromosome	Definition of DR	Population	LOD score	Nearest genetic markers	Reference
1p36	Retinopathy score in worst eye	Pima Indians	3.1	D1S3669	[50]
1p36	Any DR	Mexican; Americans	1.24	GGAT2A07	[49]
2q37	Severe NPDR/PDR	Mexican; Americans	1.11	AFM112yd4	[49]
3p26	Severe NPDR/PDR	Mexican; Americans	1.29	GATA22G12	[49]
3q12	Severe NPDR/PDR	Mexican; Americans	1.40	GATA68D03	[49]
3q12	Any DR	Mexican; Americans	2.41	GATA68D03	[49]
3q26	Presence of at least one microaneruysm, hemorrahage or proliferative DR	Pima Indians	1.36	D3S3053, D3S2427	[48]
7p15	Any DR	Mexican; Americans	1.02	GATA41G07	[49]
9q21	Presence of at least one microaneruysm, hemorrhage or proliferative DR	Pima Indians	1.46	D9S1120, D9S910	[48]
12p13	Any DR	Mexican; Americans	2.47	GATA49D12	[49]
12q23	Severe NPDR/PDR	Mexican; Americans	1.03	GATA85A04	[49]
15q25	Any DR	Mexican; Americans	1.07	ATA28G05	[49]
15q26	Any DR	Mexican; Americans	1.16	GATA22F01	[49]