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Journal of Ophthalmology
Volume 2010 (2010), Article ID 175163, 9 pages
http://dx.doi.org/10.1155/2010/175163
Review Article

ROCK as a Therapeutic Target of Diabetic Retinopathy

Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ku, Fukuoka 812-8582, Japan

Received 2 December 2009; Accepted 9 April 2010

Academic Editor: Kavita Hegde

Copyright © 2010 Ryoichi Arita et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The increasing global prevalence of diabetes is a critical problem for public health. In particular, diabetic retinopathy, a prevalent ocular complication of diabetes mellitus, causes severe vision loss in working population. A better understanding of the pathogenesis and the development of new pharmacologic treatments are needed. This paper describes the relevance between Rho/ROCK pathway and the pathogenesis of diabetic retinopathy from its early to late stages. Moreover, the therapeutic potential of ROCK inhibitor in the total management of diabetic retinopathy is discussed.