ROCK as a Therapeutic Target of Diabetic Retinopathy

Figure 3

Contractile impacts of ROCK activation in rat retinal vasculature. Intravitreal injections ofllysophosphatidic acid (LPA), Rho activator, were performed into rat’s eyes over a period of 1 minute with a 33-gauge needle. The final intraocular concentration of LPA was 20 $\mu$M. We monitored the retinal fluorescein with a scanning laser ophthalmoscope ((a) no injection, (b) 5 minutes after injection, (c) 10 minutes after injection). Intravitreal injection of induced sever retinal vessel contraction.

(a)

(b)

(c)