ERK5 Contributes to VEGF Alteration in Diabetic Retinopathy

Figure 2

ERK5 siRNA transfection reduced basal (5 mmol/l, LG) and glucose induced (25 mmol/l, HG) mRNA expression of ERK5 (a), MEF2C (b), KLF2 (c) in endothelial cells after 24 hrs of HG treatment. On the other hand, such transfection augmented VEGF mRNA expression (d). [Data are expressed as a ratio to $\beta$-actin, normalized to controls, ${}^{*}$: significantly different from control siRNA in LG, ${}^{**}$: significant difference from control siRNA in HG, $n=6$/group].

(a)

(b)

(c)

(d)