465824.fig.002a
(a)
465824.fig.002b
(b)
465824.fig.002c
(c)
465824.fig.002d
(d)
Figure 2: ERK5 siRNA transfection reduced basal (5 mmol/l, LG) and glucose induced (25 mmol/l, HG) mRNA expression of ERK5 (a), MEF2C (b), KLF2 (c) in endothelial cells after 24 hrs of HG treatment. On the other hand, such transfection augmented VEGF mRNA expression (d). [Data are expressed as a ratio to β-actin, normalized to controls, *: significantly different from control siRNA in LG, **: significant difference from control siRNA in HG, n=6/group].