521204.fig.004a
(a)
521204.fig.004b
(b)
521204.fig.004c
(c)
521204.fig.004d
(d)
Figure 4: Lens defect in AKR1B10 lens after long-term diabetes. (a) Brightfield microscopy of transgenic lens demonstrating light scattering defect (arrow). (b) AKR1B10 transgenic lens showing defect at the anterior aspect of the lens (arrow). (c) Magnification of the boxed area from panel (b). (d) Lens from nontransgenic control with equivalent duration of diabetes. Panels (b)–(d) are from toluidine blue-stained lenses.