About this Journal Submit a Manuscript Table of Contents
Journal of Ophthalmology
Volume 2010 (2010), Article ID 608751, 8 pages
http://dx.doi.org/10.1155/2010/608751
Review Article

Diabetic Cataract—Pathogenesis, Epidemiology and Treatment

Department of Ophthalmology and Optometry, Medical University Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria

Received 11 December 2009; Accepted 2 April 2010

Academic Editor: Mark Petrash

Copyright © 2010 Andreas Pollreisz and Ursula Schmidt-Erfurth. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [38 citations]

The following is the list of published articles that have cited the current article.

  • Zehra Hashim, and Shamshad Zarina, “Advanced glycation end products in diabetic and non-diabetic human subjects suffering from cataract,” Age, vol. 33, no. 3, pp. 377–384, 2011. View at Publisher · View at Google Scholar
  • Yun Mi Lee, Jin Sook Kim, Young Sook Kim, and Nan Hee Kim, “Preventive Effect of Chlorogenic Acid on Lens Opacity and Cytotoxicity in Human Lens Epithelial Cells,” Biological & Pharmaceutical Bulletin, vol. 34, no. 6, pp. 925–928, 2011. View at Publisher · View at Google Scholar
  • Milan Stefek, “Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract.,” Interdisciplinary toxicology, vol. 4, no. 2, pp. 69–77, 2011. View at Publisher · View at Google Scholar
  • Line D. Rasmussen, Line Kessel, Laleh D. Molander, Court Pedersen, Jan Gerstoft, Gitte Kronborg, and Niels Obel, “Risk of Cataract Surgery in HIV-Infected Individuals: A Danish Nationwide Population-Based Cohort Study,” Clinical Infectious Diseases, vol. 53, no. 11, pp. 1156–1163, 2011. View at Publisher · View at Google Scholar
  • Anne Vejux, Mohammad Samadi, and Gérard Lizard, “Contribution of Cholesterol and Oxysterols in the Physiopathology of Cataract: Implication for the Development of Pharmacological Treatments,” Journal of Ophthalmology, vol. 2011, pp. 1–6, 2011. View at Publisher · View at Google Scholar
  • Eydis Olafsdottir, Dan K. G. Andersson, and Einar Stefansson, “The prevalence of cataract in a population with and without type 2 diabetes mellitus,” Acta Ophthalmologica, vol. 90, no. 4, pp. 334–340, 2012. View at Publisher · View at Google Scholar
  • Michael J. Goldacre, Clare J. Wotton, and Tiarnan D. L. Keenan, “Risk of selected eye diseases in people admitted to hospital for hypertension or diabetes mellitus: record linkage studies,” British Journal Of Ophthalmology, vol. 96, no. 6, pp. 872–876, 2012. View at Publisher · View at Google Scholar
  • Mohammad Shahidullah, Amritlal Mandal, and Nicholas A. Delamere, “TRPV4 in porcine lens epithelium regulates hemichannel-mediated ATP release and Na-K-ATPase activity,” American Journal Of Physiology-Cell Physiology, vol. 302, no. 12, pp. C1751–C1761, 2012. View at Publisher · View at Google Scholar
  • Kate L. Moreau, and Jonathan A. King, “Protein misfolding and aggregation in cataract disease and prospects for prevention,” Trends In Molecular Medicine, vol. 18, no. 5, pp. 273–282, 2012. View at Publisher · View at Google Scholar
  • Yu-Wen Hsu, Shang-Min Yeh, Ya-Yu Chen, Yi-Chen Chen, Shiun-Long Lin, and Jung-Kai Tseng, “Protective effects of taurine against alloxan-induced diabetic cataracts and refraction changes in New Zealand White rabbits,” Experimental Eye Research, vol. 103, pp. 71–77, 2012. View at Publisher · View at Google Scholar
  • Raj Rajeshwari R Patil, Pratibha S Worlikar, Amol B Chaudhari, Ozhukil K Radhakrishnan, Rajendra P Gupta, and Saurabh Puri, “Effect of rifampicin and erythromycin on the initiation of galactose induced cataract in rats.,” Journal of pharmacology & pharmacotherapeutics, vol. 3, no. 4, pp. 330–2, 2012. View at Publisher · View at Google Scholar
  • Xiaoyong Wei, Dan Chen, Yanchun Yi, Hui Qi, Xinxin Gao, Hua Fang, Qiong Gu, Ling Wang, and Lianquan Gu, “Syringic Acid Extracted from Herba dendrobii Prevents Diabetic Cataract Pathogenesis by Inhibiting Aldose Reductase Activity,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, pp. 1–13, 2012. View at Publisher · View at Google Scholar
  • Yiming Li, Van H. Tran, Colin C. Duke, and Basil D. Roufogalis, “Preventive and Protective Properties of Zingiber officinale (Ginger) in Diabetes Mellitus, Diabetic Complications, and Associated Lipid and Other Metabolic Disorders: A Brief Review,” Evidence-Based Complementary and Alternative Medicine, vol. 2012, pp. 1–10, 2012. View at Publisher · View at Google Scholar
  • Qian Lu, Tingting Yang, Mingzhu Zhang, Lei Du, Ling Liu, Nan Zhang, Hao Guo, Fan Zhang, Gang Hu, and Xiaoxing Yin, “ Preventative Effects of Ginkgo biloba Extract (EGb761) on High Glucose-Cultured Opacity of Rat Lens ,” Phytotherapy Research, vol. 28, no. 5, pp. 767–773, 2013. View at Publisher · View at Google Scholar
  • Jennifer Threatt, Jennifer F. Williamson, Kyle Huynh, and Richard M. Davis, “Ocular Disease, Knowledge and Technology Applications in Patients With Diabetes,” American Journal of The Medical Sciences, vol. 345, no. 4, pp. 266–270, 2013. View at Publisher · View at Google Scholar
  • Linfeng Li, Kun-Che Chang, Yaming Zhou, Biehuoy Shieh, Jessica Ponder, Adedoyin D. Abraham, Hadi Ali, Anson Snow, J. Mark Petrash, and Daniel V. LaBarbera, “ Design of an Amide N -Glycoside Derivative of β-Glucogallin: A Stable, Potent, and Specific Inhibitor of Aldose Reductase ,” Journal of Medicinal Chemistry, pp. 131223112402003, 2013. View at Publisher · View at Google Scholar
  • M. R. Manaviat, Nasim Oveisi, and  A. Zare-Bidoki, “Accelerated Bilateral Cataract Formation as a First Manifestation of Diabetes Mellitus,” Prague Medical Report, vol. 114, no. 4, pp. 258–262, 2013. View at Publisher · View at Google Scholar
  • Haleh Ghaem Maralani, Bee Choo Tai, Tien Y. Wong, E. Shyong Tai, Jialiang Li, Jie Jin Wang, and Paul Mitchell, “Metabolic Syndrome and Risk of Age-Related Cataract over Time: An Analysis of Interval-Censored Data Using a Random-Effects Model,” Investigative Ophthalmology & Visual Science, vol. 54, no. 1, pp. 641–646, 2013. View at Publisher · View at Google Scholar
  • Tânia Melo, Eduarda M. P. Silva, Cláudia Simões, Pedro Domingues, and M. Rosário M. Domingues, “Photooxidation of glycated and non-glycated phosphatidylethanolamines monitored by mass spectrometry,” Journal of Mass Spectrometry, vol. 48, no. 1, pp. 68–78, 2013. View at Publisher · View at Google Scholar
  • Tomoyuki Kawada, “Risk of Lens Opacity in Patients with Diabetes Mellitus,” Ophthalmology, vol. 120, no. 7, pp. E44–E45, 2013. View at Publisher · View at Google Scholar
  • Xiaojian Gong, Qiuyan Zhang, and Shuhua Tan, “Inhibitory Effect of r-Hirudin Variant III on Streptozotocin-Induced Diabetic Cataracts in Rats,” The Scientific World Journal, vol. 2013, pp. 1–8, 2013. View at Publisher · View at Google Scholar
  • Martina Tomić, Spomenka Ljubić, Snježana Kaštelan, Antonela Gverović Antunica, Anamarija Jazbec, and Tamara Poljičanin, “Inflammation, Haemostatic Disturbance, and Obesity: Possible Link to Pathogenesis of Diabetic Retinopathy in Type 2 Diabetes,” Mediators of Inflammation, vol. 2013, pp. 1–10, 2013. View at Publisher · View at Google Scholar
  • Krishnaswamy Kannan, Ilangovan Raju, and Edathara C. Abraham, “FoxO3a Serves as a Biomarker of Oxidative Stress in Human Lens Epithelial Cells under Conditions of Hyperglycemia,” Plos One, vol. 8, no. 6, 2013. View at Publisher · View at Google Scholar
  • Nagihan Ugurlu, Fatma Yulek, Sule Berk Ergun, Mehmet Dogan Asik, Semra Isikoglu, and Emine Akcay, “Investigation of oxidative and antioxidative status in patients with diabetic cataracts,” Turkish Journal of Medical Sciences, vol. 43, no. 5, pp. 678–683, 2013. View at Publisher · View at Google Scholar
  • Anupam Samanta, Premranjan Kumar, Sanghamitra Machhua, G. Nageswar Rao, and Arttatrana Pal, “Incidence of cystoid macular oedema in diabetic patients after phacoemulsification and free radical link to its pathogenesis,” British Journal of Ophthalmology, vol. 98, no. 9, pp. 1266–1272, 2014. View at Publisher · View at Google Scholar
  • Yue-Hua Wang, Yu-Pei Han, Hai-Tao Yu, Xiao-Ping Pu, and Guan-Hua Du, “Protocatechualdehyde prevents methylglyoxal-induced mitochondrial dysfunction and AGEs-RAGE axis activation in Human lens epithelial cells,” European Journal of Pharmacology, vol. 738, pp. 374–383, 2014. View at Publisher · View at Google Scholar
  • Li Li, Xiu-Hua Wan, and Guo-Hong Zhao, “Meta-analysis of the risk of cataract in type 2 diabetes,” Bmc Ophthalmology, vol. 14, 2014. View at Publisher · View at Google Scholar
  • Yue-Hua Wang, Yu-Pei Han, Hai-Tao Yu, Xiao-Ping Pu, and Guan-Hua Du, “Protocatechualdehyde prevents methylglyoxal-induced mitochondrial dysfunction and AGEs-RAGE axis activation in Human lens epithelial cells,” European Journal of Pharmacology, 2014. View at Publisher · View at Google Scholar
  • Periyasamy Palsamy, Keshore R. Bidasee, Masahiko Ayaki, Robert C. Augusteyn, Jefferson Y. Chan, and Toshimichi Shinohara, “Methylglyoxal induces endoplasmic reticulum stress and DNA demethylation in the Keap1 promoter of human lens epithelial cells and age-related cataracts,” Free Radical Biology and Medicine, 2014. View at Publisher · View at Google Scholar
  • Jochen Graw, “Genetic models for cataracts,” Drug Discovery Today: Disease Models, 2014. View at Publisher · View at Google Scholar
  • Lei Sun, De-Jing Shi, Xiang-Chun Gao, Shu-Yong Mi, Ying Yu, and Qing Han, “The Protective Effect of Vanadium Against Diabetic Cataracts in Diabetic Rat Model,” Biological Trace Element Research, 2014. View at Publisher · View at Google Scholar
  • Ying Wang, Andrea O. Y. Luk, Maggie C. Y. Ng, Calvin C. P. Pang, Vincent Lam, Shao C. Lee, Dennis S. C. Lam, Kwong Wai Choy, Ronald C. W. Ma, Wing-Yee So, and Juliana C. N. Chan, “Additive effect of aldose reductase Z-4 microsatellite polymorphism and glycaemic control on cataract development in type 2 diabetes,” Journal of Diabetes and Its Complications, vol. 28, no. 2, pp. 147–151, 2014. View at Publisher · View at Google Scholar
  • Daniel Petrovic, “Aldose reductase, glucose and cataracts,” Journal of Diabetes and Its Complications, vol. 28, no. 2, pp. 120–121, 2014. View at Publisher · View at Google Scholar
  • Nour Maya N. Haddad, Jennifer K. Sun, Samer Abujaber, Deborah K. Schlossman, and Paolo S. Silva, “Cataract Surgery and its Complications in Diabetic Patients,” Seminars in Ophthalmology, vol. 29, no. 5-6, pp. 329–337, 2014. View at Publisher · View at Google Scholar
  • Sanja Mitrović, Tomislav Kelava, Alan Šućur, and Danka Grčević, “Levels of Selected Aqueous Humor Mediators (IL-10, IL-17, CCL2, VEGF, FasL) in Diabetic Cataract,” Ocular Immunology and Inflammation, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • Beatriz E. Torres-Bernal, Luis Fernando Torres-Bernal, Rafael R. Gutiérrez-Campos, David D. Kershenobich Stalnikowitz, Luis Fernando Barba-Gallardo, Arturo A. Chayet, and Javier Ventura-Juárez, “Unfolded protein response activation in cataracts,” Journal of Cataract & Refractive Surgery, vol. 40, no. 10, pp. 1697–1705, 2014. View at Publisher · View at Google Scholar
  • Varun Parkash Singh, Anjana Bali, Nirmal Singh, and Amteshwar Singh Jaggi, “Advanced Glycation End Products and Diabetic Complications,” The Korean Journal of Physiology & Pharmacology, vol. 18, no. 1, pp. 1, 2014. View at Publisher · View at Google Scholar
  • Paphaphat Thiraphatthanavong, Jintanaporn Wattanathorn, Supaporn Muchimapura, Wipawee Thukham-mee, Panakaporn Wannanon, Terdthai Tong-un, Bhalang Suriharn, and Kamol Lertrat, “Preventive Effect of Zea mays L. (Purple Waxy Corn) on Experimental Diabetic Cataract,” BioMed Research International, vol. 2014, pp. 1–8, 2014. View at Publisher · View at Google Scholar