Figure 1: Nonfasting plasma insulin and glucose levels in Spontaneously Diabetic Torii (SDT) rats and control Sprague-Dawley (SD) rats. Diminish of pancreatic β-cells evokes hypoinsulinemia (a) and subsequent severe hyperglycemia (b) in SDT rats. Plasma glucose levels sharply increase at 15–20 weeks of age and eventually reach a plateau, approximately 800 mg/dL. Each value represents mean ± S.E.M. (N = 6–8).