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Journal of Ophthalmology
Volume 2010 (2010), Article ID 615641, 7 pages
http://dx.doi.org/10.1155/2010/615641
Review Article

Pathophysiological Characteristics of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rat

Biological/Pharmacological Research Laboratories, Central Pharmaceutical Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

Received 29 November 2009; Accepted 26 March 2010

Academic Editor: Mark Petrash

Copyright © 2010 Tomohiko Sasase. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. R. Mansford and L. Opie, “Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan,” Lancet, vol. 1, no. 7544, pp. 670–671, 1968. View at Scopus
  2. S. Makino, K. Kunimoto, Y. Muraoka, Y. Mizushima, K. Katagiri, and Y. Tochino, “Breeding of a non-obese, diabetic strain of mice,” Jikken Dobutsu, vol. 29, no. 1, pp. 1–13, 1980 (Japanese). View at Scopus
  3. A. F. Nakhooda, A. A. Like, C. I. Chappel, F. T. Murray, and E. B. Marliss,, “The spontaneously diabetic Wistar rat. Metabolic and morphologic studies,” Diabetes, vol. 26, no. 2, pp. 100–112, 1977. View at Scopus
  4. D. L. Coleman and K. P. Hummel, “The influence of genetic background on the expression of the obese (Ob) gene in the mouse,” Diabetologia, vol. 9, no. 4, pp. 287–293, 1973. View at Scopus
  5. D. L. Coleman and K. P. Hummel, “Hyperinsulinemia in pre weaning diabetes (db) mice,” Diabetologia, vol. 10, no. 5, pp. 607–610, 1974. View at Scopus
  6. Y. Goto, K. Suzuki, T. Ono, M. Sasaki, and T. Toyota, “Development of diabetes in the non-obese NIDDM rat (GK rat),” Advances in Experimental Medicine and Biology, vol. 246, pp. 29–31, 1988. View at Scopus
  7. J. B. Clark, C. J. Palmer, and W. N. Shaw, “The diabetic Zucker fatty rat,” Proceedings of the Society for Experimental Biology and Medicine, vol. 173, no. 1, pp. 68–75, 1983. View at Scopus
  8. K. Kawano, T. Hirashima, S. Mori, Y. Saitoh, M. Kurosumi, and T. Natori, “Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain,” Diabetes, vol. 41, no. 11, pp. 1422–1428, 1992. View at Scopus
  9. W. G. Robison Jr., M. Nagata, N. Laver, T. C. Hohman, and J. H. Kinoshita, “Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor,” Investigative Ophthalmology & Visual Science, vol. 30, no. 11, pp. 2285–2292, 1989. View at Scopus
  10. N. Miyamura, I. A. Bhutto, and T. Amemiya, “Retinal capillary changes in Otsuka Long-Evans Tokushima fatty rats (spontaneously diabetic strain). Electron-microscopic study,” Ophthalmic Research, vol. 31, no. 5, pp. 358–366, 1999. View at Publisher · View at Google Scholar · View at Scopus
  11. K. Miyamoto, N. Hiroshiba, A. Tsujikawa, and Y. Ogura, “In vivo demonstration of increased leukocyte entrapment in retinal microcirculation of diabetic rats,” Investigative Ophthalmology & Visual Science, vol. 39, no. 11, pp. 2190–2194, 1998. View at Scopus
  12. H. Sakai, Y. Tani, E. Shirasawa, Y. Shirao, and K. Kawasaki, “Development of electroretinographic alterations in streptozotocin-induced diabetes in rats,” Ophthalmic Research, vol. 27, no. 1, pp. 57–63, 1995. View at Scopus
  13. M. Shinohara, T. Masuyama, T. Shoda, et al., “A new spontaneously diabetic non-obese torii rat strain with severe ocular complications,” International Journal of Experimental Diabetes Research, vol. 1, no. 2, pp. 89–100, 2000. View at Scopus
  14. M. Shinohara, T. Masuyama, and A. Kakehashi, “The Spontaneously Diabetic Torii (SDT) rat with retinopathy lesions resembling those of humans,” in Animal Models of Diabetes: Frontiers in Research, E. Shafrir, Ed., pp. 311–321, CRC Press, Boca Raton, Fla, USA, 2nd edition, 2007.
  15. H. Yamada, E. Yamada, A. Higuchi, and M. Matsumura, “Retinal neovascularisation without ischaemia in the spontaneously diabetic Torii rat,” Diabetologia, vol. 48, no. 8, pp. 1663–1668, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Kakehashi, Y. Saito, K. Mori, et al., “Characteristics of diabetic retinopathy in SDT rats,” Diabetes/Metabolism Research and Reviews, vol. 22, no. 6, pp. 455–461, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Sasase, N. Ohta, K. Ogawa, et al., “Preventive effects of glycaemic control on ocular complications of Spontaneously Diabetic Torii rat,” Diabetes, Obesity and Metabolism, vol. 8, no. 5, pp. 501–507, 2006. View at Publisher · View at Google Scholar · View at Scopus
  18. T. Shoda, M. Shinohara, T. Takahashi, K. Miyajima, A. Kakehashi, and Y. Miyakawa, “Histopathological features of diabetic ocular complications in the Spontaneously Diabetic Torii (SDT) rat,” Journal of Toxicologic Pathology, vol. 20, no. 3, pp. 179–183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. T. Sasase, T. Ohta, and N. Ogawa, “Diabetic complications of Spontaneously Diabetic Torii rat,” Diabetes, vol. 54, supplement 1, p. A221, 2005.
  20. T. Sasase, H. Morinaga, T. Abe, et al., “Protein kinase C beta inhibitor prevents diabetic peripheral neuropathy, but not histopathological abnormalities of retina in Spontaneously Diabetic Torii rat,” Diabetes, Obesity and Metabolism, vol. 11, no. 11, pp. 1084–1087, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Ohta, K. Matsui, K. Miyajima, et al., “Effect of insulin therapy on renal changes in spontaneously diabetic Torii rats,” Experimental Animals, vol. 56, no. 5, pp. 355–362, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. T. Masuyama, K. Komeda, A. Hara, et al., “Chronological characterization of diabetes development in male Spontaneously Diabetic Torii rats,” Biochemical and Biophysical Research Communications, vol. 314, no. 3, pp. 870–877, 2004. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Sasase, H. Morinaga, H. Yamamoto, et al., “Increased fat absorption and impaired fat clearance cause postprandial hypertriglyceridemia in Spontaneously Diabetic Torii rat,” Diabetes Research and Clinical Practice, vol. 78, no. 1, pp. 8–15, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. T. Masuyama, M. Fuse, N. Yokoi, et al., “Genetic analysis for diabetes in a new rat model of nonobese type 2 diabetes, Spontaneously Diabetic Torii rat,” Biochemical and Biophysical Research Communications, vol. 304, no. 1, pp. 196–206, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. K. Matsui, T. Oda, E. Nishizawa, et al., “Pancreatic function of spontaneously diabetic torii rats in pre-diabetic stage,” Experimental Animals, vol. 58, no. 4, pp. 363–374, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Fuse, N. Yokoi, M. Shinohara, et al., “Identification of a major locus for islet inflammation and fibrosis in the spontaneously diabetic Torii rat,” Physiological Genomics, vol. 35, no. 1, pp. 96–105, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Miao, T. Ito, F. Uchikoshi, et al., “Stage-dependent effect of pancreatic transplantation on diabetic ocular complications in the Spontaneously Diabetic Torii rat,” Transplantation, vol. 77, no. 5, pp. 658–663, 2004. View at Publisher · View at Google Scholar · View at Scopus
  28. A. Kakehashi and M. Kanazawa, “SDT rat: a new diabetic retinopathy animal model,” Endocrinology & Diabetology, vol. 12, no. 4, pp. 386–390, 2001 (Japanese).
  29. D. Yonemura, T. Aoki, and K. Tsuzuki, “Electroretinogram in diabetic retinopathy,” Archives of Ophthalmology, vol. 68, pp. 19–24, 1962.
  30. P. Algvere, “Clinical studies on the oscillatory potentials of the human electroretinogram with special reference to the scotopic b-wave,” Acta Ophthalmologica, vol. 46, no. 5, pp. 993–1024, 1968. View at Scopus
  31. N. Hotta, N. Koh, F. Sakakibara, et al., “Effects of beraprost sodium and insulin on the electroretinogram, nerve conduction, and nerve blood flow in rats with streptozotocin-induced diabetes,” Diabetes, vol. 45, no. 3, pp. 361–366, 1996. View at Scopus
  32. N. Hotta, N. Koh, F. Sakakibara, et al., “Effects of propionyl-L-carnitine and insulin on the electroretinogram, nerve conduction and nerve blood flow in rats with streptozotocin-induced diabetes,” Pflügers Archiv European Journal of Physiology, vol. 431, no. 4, pp. 564–570, 1996. View at Publisher · View at Google Scholar · View at Scopus
  33. T. Okuno, H. Oku, T. Sugiyama, and T. Ikeda, “Electroretinographic study of spontaneously diabetic Torii rats,” Documenta Ophthalmologica, vol. 117, no. 3, pp. 191–196, 2008. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Sugiyama, T. Okuno, M. Fukuhara, et al., “Angiotensin II receptor blocker inhibits abnormal accumulation of advanced glycation end products and retinal damage in a rat model of type 2 diabetes,” Experimental Eye Research, vol. 85, no. 3, pp. 406–412, 2007. View at Publisher · View at Google Scholar · View at Scopus
  35. N. Ferrara, K. A. Houck, L. B. Jakeman, J. Winer, and D. W. Leung, “The vascular endothelial growth factor family of polypeptides,” Journal of Cellular Biochemistry, vol. 47, no. 3, pp. 211–218, 1991. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Klagsbrun and P. A. D'Amore, “Vascular endothelial growth factor and its receptors,” Cytokine & Growth Factor Reviews, vol. 7, no. 3, pp. 259–270, 1996. View at Publisher · View at Google Scholar · View at Scopus
  37. A. P. Adamis, J. W. Miller, M.-T. Bernal, et al., “Increased vascular endothelial growth factor levels in the vitreous of eyes with proliferative diabetic retinopathy,” American Journal of Ophthalmology, vol. 118, no. 4, pp. 445–450, 1994.
  38. L. P. Aiello, R. L. Avery, P. G. Arrigg, et al., “Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders,” The New England Journal of Medicine, vol. 331, no. 22, pp. 1480–1487, 1994. View at Publisher · View at Google Scholar · View at Scopus
  39. H. Funatsu, H. Yamashita, H. Noma, T. Mimura, T. Yamashita, and S. Hori, “Increased levels of vascular endothelial growth factor and interleukin-6 in the aqueous humor of diabetics with macular edema,” American Journal of Ophthalmology, vol. 133, no. 1, pp. 70–77, 2002. View at Publisher · View at Google Scholar · View at Scopus
  40. M. Matsuoka, N. Ogata, K. Minamino, A. Higuchi, and M. Matsumura, “High levels of pigment epithelium-derived factor in the retina of a rat model of type 2 diabetes,” Experimental Eye Research, vol. 82, no. 1, pp. 172–178, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. M. Fukumoto, S. Takai, E. Ishizaki, et al., “Involvement of angiotensin II-dependent vascular endothelial growth factor gene expression via NADPH oxidase in the retina in a type 2 diabetic rat model,” Current Eye Research, vol. 33, no. 10, pp. 885–891, 2008. View at Publisher · View at Google Scholar · View at Scopus
  42. J. Ideno, H. Mizukami, A. Kakehashi, et al., “Prevention of diabetic retinopathy by intraocular soluble flt-1 gene transfer in a spontaneously diabetic rat model,” International Journal of Molecular Medicine, vol. 19, no. 1, pp. 75–79, 2007. View at Scopus
  43. D. W. Dawson, O. V. Volpert, P. Gillis, et al., “Pigment epithelium-derived factor: a potent inhibitor of angiogenesis,” Science, vol. 285, no. 5425, pp. 245–248, 1999. View at Publisher · View at Google Scholar · View at Scopus
  44. M. Matsuoka, N. Ogata, K. Minamino, and M. Matsumura, “Leukostatis and pigment epithelium-derived factor in rat models of diabetic retinopathy,” Molecular Vision, vol. 13, pp. 1058–1065, 2007. View at Scopus
  45. J. Spranger, M. Osterhoff, M. Reimann, et al., “Loss of the antiangiogenic pigment epithelium-derived factor in patients with angiogenic eye disease,” Diabetes, vol. 50, no. 12, pp. 2641–2645, 2001. View at Scopus
  46. W. G. Robinson Jr., J. L. McCaleb, L. G. Feld, O. E. Michaelis IV, N. Laver, and M. Mercandetti, “Degenerated intramural pericytes (‘ghost cells’) in the retinal capillaries of diabetic rats,” Current Eye Research, vol. 10, no. 4, pp. 339–350, 1991. View at Scopus
  47. R. N. Frank, “Diabetic retinopathy,” The New England Journal of Medicine, vol. 350, no. 1, pp. 48–58, 2004. View at Scopus
  48. A. Kanamori, M. Nakamura, H. Mukuno, H. Maeda, and A. Negi, “Diabetes has an additive effect on neural apoptosis in rat retina with chronically elevated intraocular pressure,” Current Eye Research, vol. 28, no. 1, pp. 47–54, 2004. View at Publisher · View at Google Scholar · View at Scopus
  49. S. X. Zhang, J. Sima, C. Shao, et al., “Plasminogen kringle 5 reduces vascular leakage in the retina in rat models of oxygen-induced retinopathy and diabetes,” Diabetologia, vol. 47, no. 1, pp. 124–131, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. A. Jariyapongskul, T. Rungjaroen, N. Kasetsuwan, S. Pathumraj, and H. Niimi, “Chronic changes of the iris microvasculature of streptozotocin-induced diabetic rats using fluorescence videomicroscopy,” Clinical Hemorheology and Microcirculation, vol. 34, no. 1-2, pp. 283–293, 2006. View at Scopus
  51. T. Masuyama, Y. Katsuda, and M. Shinohara, “A novel model of obesity-related diabetes: introgression of the Leprfa allele of the Zucker fatty rat into nonobese Spontaneously Diabetic Torii (SDT) rats,” Experimental Animals, vol. 54, no. 1, pp. 13–20, 2005. View at Publisher · View at Google Scholar · View at Scopus
  52. K. Matsui, T. Ohta, T. Oda, et al., “Diabetes-associated complications in Spontaneously Diabetic Torii fatty rats,” Experimental Animals, vol. 57, no. 2, pp. 111–121, 2008. View at Publisher · View at Google Scholar · View at Scopus