Table 2: Top 10 single-marker associations with severe diabetic retinopathy among Mexican-Americans from Starr County, Texas.

dbSNP rs#ChrPosition*Minor/major alleleMAF in CasesMAF in ControlsP-value§OR+ (95%CI)Nearest gene*Distance/
relationship to gene

rs23007825110816684A/G0.5120.3226.04E-052.64 (1.64–4.25)CAMK4intron/0
rs105197651530992716A/G0.1360.2946.21E-050.30 (0.16–0.54)FMN1intron/0
rs8990361141639486C/A0.1250.2102.52E-040.32 (0.17–0.59)API5upstream/
1650623
rs105019431199452209C/T0.1950.0862.53E-043.04 (1.68–5.52)CNTN5intron/0
rs1445754583611387A/T0.1430.2733.35E-040.37 (0.22–0.64)EDIL3intron/0
rs11973103134610914T/A0.5400.4353.35E-042.25 (1.45–3.51)BFSP2intron/0
rs69954924683138T/C0.1150.0433.49E-044.27 (1.93–9.47)
rs7639702138352603A/C0.3300.2064.00E-042.25 (1.44–3.52)HNMTupstream/
85675
rs59901918284495G/T0.0300.1314.06E-040.15 (0.05–0.43)COLEC12downstream/
24861
rs64272471168647104G/A0.3600.2214.56E-042.17 (1.41–3.35)SCYL1BP1upstream/
120790

*Affymetrix NetAffx annotation build 25, NCBI genome build 36.1.
§P-value of logistic regression under additive genetic model, adjusted for age, gender, diabetes duration, and HbA1c level.
+odds ratios of the minor allele.