Research Article

Mouse Model Resources for Vision Research

Figure 3

The mouse model . (a) Direct sequencing of control and homozygous mutant identified an A to T mutation, predicting early termination at Arg522. The position of the mutation is highlighted and an asterisk indicates the termination. (b) The retinal morphology of control and mice was examined at 1 and 3 months of age (mo). OSs: outer segments, ISs: inner segments, ONL: outer nuclear layer, OPL: outer plexiform layer, INL: inner nuclear layer. Scale bar = 20  m. (c) Electroretinogram of dark-adapted (scotopic) and light-adapted (photopic) control at 9 weeks of age and at 4 weeks of age. (d) The amplitude of dark-adapted a and b-wave and light-adapted b-wave ( SEM, = 3) of 4 weeks old mice and age matched controls.
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