Research Article

Mouse Model Resources for Vision Research

Table 1

Mouse retinal mutants maintained in the Eye Mutant Resource (EMR) at The Jackson Laboratory.

ModelModeGeneChr.Clinical Phenotype

rd1ARPde6b5Early onset, severe retinal degeneration [24]
pcdARAgtpbp113Slower retinal degeneration associated with Purkinje cell degeneration [25]
nrARUN8Progressive retinal degeneration with hyperactive ataxic behavior (nervous) [25]
Rd2ADPrph217Slow progressive retinal degeneration [26]
rd3ARRd31Retinal degeneration, beginning at 3 weeks of age [27]
Rd4ADGnb14Autosomal dominant retinal degeneration [28]
TubARTub7Retinal degeneration, hearing loss, and late-developing obesity, also known as rd5 [29]
mndARCln88Early onset retinal degeneration with a late-onset progressive motor neuron degeneration [30]
rd6ARMfrp9Small, white retinal spots and progressive photoreceptor degeneration [31]
rd7ARNr2e39Retinal spots and progressive photoreceptor degeneration [32]
rd8ARCrb11Focal photoreceptor degeneration [33]
Rd9XDUNXProgressive retinal white spotting and degeneration [33]
rd10ARPde6b5Early onset, mild retinal degeneration [34]
rd11ARLpcat113Retinal degeneration with white retinal vessels at 4 weeks of age [35]
rd12ARRpe653Poor ERG response and late onset retinal degeneration [36]
rd14ARUN18Slow retinal degeneration with white retinal spots [37]
rd15ARUN7Retinal degeneration with retinal outer plexiform dystrophy [38]
rd16ARCep29010Early onset retinal degeneration [39]
rd17ARGnat19Poor rod ERG response and slow retinal degeneration [40]
cpfl1ARPde6c19Cone photoreceptor function loss-1 [41]
Cpfl2ADUN3Cone photoreceptor function loss-2 with white retinal spots [42]
cpfl3ARGnat23Cone photoreceptor function loss-3 [43]
Cpfl4ADUN17Cone photoreceptor function loss-4 [44]
cpfl5ARCnga31Cone photoreceptor function loss-5 [45]
cpfl6ARHcn113Cone photoreceptor function loss-6 [46]
cpfl7ARUN19Cone photoreceptor function loss-7 [47]
nob2XRCacna1fXAnatomical and functional abnormalities (no b-wave-2) in the outer retina [48]
nob3ARGrm611Retinal functional abnormalities (no b-wave 3) [49]
arrd2ARMdm110Age-related retinal degeneration-2 [50]

AR: autosomal recessive, AD: autosomal dominant, XR: X-linked recessive, UN: unknown.