Research Article

Mouse Model Resources for Vision Research

Table 2

Mouse mutants from the Translational Vision Research Models (TVRMs) program in which the molecular basis for the disease phenotype has been identified.

ModelModeGeneChr.Clinical Phenotype

tvrm64ARRp1 1Juvenile onset retinal degeneration
nmf12ARMertk 2Late onset slow degeneration
tvrm148ARRpe65 3Late onset retinal degeneration
nmf192ARNphp4 4Early rapid retinal degeneration
nmf364ARPde6b* 5Early rapid retinal degeneration
nmf449ARPde6b* 5Early rapid retinal degeneration
Tvrm1ADRho 6Light inducible retinal degeneration [51]
Tvrm4ADRho 6Light inducible retinal degeneration [51]
Tvrm144ADRho 6Light inducible retinal degeneration
tvrm65ARCrx 7Early rapid retinal degeneration
tvrm27ARTrpm1 7No B-wave
tvrm89ARMyo6 9Attenuated ERG
tvrm84ARGrm110Attenuated ERG
nmf246ARUchl314Juvenile onset retinal degeneration
nmf247ARRpgrip114Early rapid retinal degeneration [52]
nmf5aARPfnd515Early rapid retinal degeneration
nmf240ARClcn216Early rapid retinal degeneration [53]
nmf223ARLama117Vitreal fibroplasia, vascular abnormalities [54]
tvrm124ARTulp1*17Early rapid retinal degeneration
nmf282ARPde6a18Early rapid retinal degeneration [55]
nmf363ARPde6a18Early rapid retinal degeneration [55]
tvrm58ARPde6a*18Early rapid retinal degeneration
tvrm32ARHps1*18Pigmentation defect

*Established by complementation testing.