Journal of Ophthalmology / 2011 / Article / Tab 2 / Research Article
Mouse Model Resources for Vision Research Table 2 Mouse mutants from the Translational Vision Research Models (TVRMs) program in which the molecular basis for the disease phenotype has been identified.
Model Mode Gene Chr. Clinical Phenotype tvrm64 AR Rp1 1 Juvenile onset retinal degeneration nmf12 AR Mertk 2 Late onset slow degeneration tvrm148 AR Rpe65 3 Late onset retinal degeneration nmf192 AR Nphp4 4 Early rapid retinal degeneration nmf364 AR Pde6b* 5 Early rapid retinal degeneration nmf449 AR Pde6b* 5 Early rapid retinal degeneration Tvrm1 AD Rho 6 Light inducible retinal degeneration [51 ] Tvrm4 AD Rho 6 Light inducible retinal degeneration [51 ] Tvrm144 AD Rho 6 Light inducible retinal degeneration tvrm65 AR Crx 7 Early rapid retinal degeneration tvrm27 AR Trpm1 7 No B-wave tvrm89 AR Myo6 9 Attenuated ERG tvrm84 AR Grm1 10 Attenuated ERG nmf246 AR Uchl3 14 Juvenile onset retinal degeneration nmf247 AR Rpgrip1 14 Early rapid retinal degeneration [52 ] nmf5a AR Pfnd5 15 Early rapid retinal degeneration nmf240 AR Clcn2 16 Early rapid retinal degeneration [53 ] nmf223 AR Lama1 17 Vitreal fibroplasia, vascular abnormalities [54 ] tvrm124 AR Tulp1* 17 Early rapid retinal degeneration nmf282 AR Pde6a 18 Early rapid retinal degeneration [55 ] nmf363 AR Pde6a 18 Early rapid retinal degeneration [55 ] tvrm58 AR Pde6a* 18 Early rapid retinal degeneration tvrm32 AR Hps1* 18 Pigmentation defect
*Established by complementation testing.