Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection
Figure 2
STAT3 activation and rhodopsin protein levels in the retina of EIU model generated in SOCS3CKO mice. Immunoblot analyses. In the SOCS3CKO retina, phosphorylated and activated STAT3 are upregulated in the control condition, and more greatly increased in the EIU model induced by LPS (a, c). Although the rhodopsin protein level in the adult SOCS3CKO retina is almost the same as wild-type retina under control condition, its level was more severely reduced in the EIU model induced by LPS (b, d). WT: wild-type; KO, SOCS3CKO; LPS: lipopolysaccharide; pSTAT3: phosphorylated STAT3; EIU: endotoxin-induced uveitis. This research was originally published in J Biol Chem. Ozawa Y, et al. Roles of STAT3/SOCS3 Pathway in Regulating the Visual Function and Ubiquitin-Proteasome-dependent Degradation of Rhodopsin during Retinal Inflammation. J Biol Chem. 2008; 283(36):24561–24570. the American Society for Biochemistry and Molecular Biology.
