Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection

<table><i>Model of the molecular mechanism in diabetic retinopathy.</i> Angiotensin II binds to AT1R and induces ERK activation, resulting in excessive UPS-mediated synaptophysin protein degradation. This impairs synaptic activity, which is critical for visual function and neuronal cell survival.</table>

Journal of Ophthalmology

fig5

Figure 5

Figure 5: Regulation of Posttranscriptional Modification as a Possible Therapeutic Approach for Retinal Neuroprotection 