Cellular Origin of Spontaneous Ganglion Cell Spike Activity in Animal Models of Retinitis Pigmentosa
Figure 3
Loose patch extracellular recording of spontaneous spike activity from wild-type (non-dystrophic) retinal ganglion cell perfused with Control Ames solution without (top traces (a) and (b)) and with (lower traces (a) and (b)) the addition of mixture of inhibitory synaptic blockers containing 40 uM Gabazine, 50 uM TPMPA, and 1 uM Strychnine. Boxed region outlined by the dash lines in (a) are shown on a faster time in (b). The trace shown on an expanded time scale in control Ames (b) was taken from a region of trace in (a) that was shifted to the right to avoid the period of baseline instability.
