The Domestic Cat as a Large Animal Model for Characterization of Disease and Therapeutic Intervention in Hereditary Retinal Blindness
Figure 1
Fundus appearance and electroretinograms (ERGs) of rdAc individuals with the CEP290 mutation. Fundus photographs demonstrate (a) a 1-year-old unaffected Abyssinian cat (wildtype, WT), (b) a 2-year-old affected Abyssinian cat with an early disease stage (S2) [39], and (c) a 6-year-old Abyssinian with an advanced disease stage (S4) [39]. Arrows in (b) and (c) indicate retinal vasculature that is attenuated, more so in the advanced stage (c) than in early stage of disease (b). For the same three cats, the waveforms of the dark-adapted full-field flash ERG recordings are shown, using 4 cd.s/m2 of white light stimulation for each of the recordings. Amplitude and implicit time calibrations are indicated in the figure, vertically and horizontally, respectively. Reproduced with permission from [43].
